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Mycobacterium tuberculosis lipoprotein and lipoglycan binding to Toll-like receptor 2 correlates with agonist activity and functional outcomes.

Shukla S, Richardson ET, Drage MG, Boom WH, Harding CV.

Infect Immun. 2018 Jul 23. pii: IAI.00450-18. doi: 10.1128/IAI.00450-18. [Epub ahead of print]


Bacterial Membrane Vesicles Mediate the Release of Mycobacterium tuberculosis Lipoglycans and Lipoproteins from Infected Macrophages.

Athman JJ, Wang Y, McDonald DJ, Boom WH, Harding CV, Wearsch PA.

J Immunol. 2015 Aug 1;195(3):1044-53. doi: 10.4049/jimmunol.1402894. Epub 2015 Jun 24.


Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells.

Richardson ET, Shukla S, Sweet DR, Wearsch PA, Tsichlis PN, Boom WH, Harding CV.

Infect Immun. 2015 Jun;83(6):2242-54. doi: 10.1128/IAI.00135-15. Epub 2015 Mar 16.


TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.

Reba SM, Li Q, Onwuzulike S, Ding X, Karim AF, Hernandez Y, Fulton SA, Harding CV, Lancioni CL, Nagy N, Rodriguez ME, Wearsch PA, Rojas RE.

Eur J Immunol. 2014 May;44(5):1410-21. doi: 10.1002/eji.201344100. Epub 2014 Mar 14.


TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9.

Liu YC, Simmons DP, Li X, Abbott DW, Boom WH, Harding CV.

J Immunol. 2012 Feb 1;188(3):1019-26. doi: 10.4049/jimmunol.1102181. Epub 2012 Jan 6.


Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.

Lancioni CL, Li Q, Thomas JJ, Ding X, Thiel B, Drage MG, Pecora ND, Ziady AG, Shank S, Harding CV, Boom WH, Rojas RE.

Infect Immun. 2011 Feb;79(2):663-73. doi: 10.1128/IAI.00806-10. Epub 2010 Nov 15.


Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.

Drage MG, Tsai HC, Pecora ND, Cheng TY, Arida AR, Shukla S, Rojas RE, Seshadri C, Moody DB, Boom WH, Sacchettini JC, Harding CV.

Nat Struct Mol Biol. 2010 Sep;17(9):1088-95. doi: 10.1038/nsmb.1869. Epub 2010 Aug 8.


Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9.

Simmons DP, Canaday DH, Liu Y, Li Q, Huang A, Boom WH, Harding CV.

J Immunol. 2010 Aug 15;185(4):2405-15. doi: 10.4049/jimmunol.0904005. Epub 2010 Jul 21.


Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling.

Shin DM, Yuk JM, Lee HM, Lee SH, Son JW, Harding CV, Kim JM, Modlin RL, Jo EK.

Cell Microbiol. 2010 Nov;12(11):1648-65. doi: 10.1111/j.1462-5822.2010.01497.x. Epub 2010 Jul 20.


Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors.

Harding CV, Boom WH.

Nat Rev Microbiol. 2010 Apr;8(4):296-307. doi: 10.1038/nrmicro2321. Review.


TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.

Drage MG, Pecora ND, Hise AG, Febbraio M, Silverstein RL, Golenbock DT, Boom WH, Harding CV.

Cell Immunol. 2009;258(1):29-37. doi: 10.1016/j.cellimm.2009.03.008. Epub 2009 Apr 11.


Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells.

Liang H, Russell RS, Yonkers NL, McDonald D, Rodriguez B, Harding CV, Anthony DD.

J Virol. 2009 Jun;83(11):5693-707. doi: 10.1128/JVI.02671-08. Epub 2009 Mar 18.


Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages.

Shin DM, Yang CS, Lee JY, Lee SJ, Choi HH, Lee HM, Yuk JM, Harding CV, Jo EK.

Cell Microbiol. 2008 Sep;10(9):1893-905. doi: 10.1111/j.1462-5822.2008.01179.x. Epub 2008 Jul 15.


Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.

Funderburg N, Lederman MM, Feng Z, Drage MG, Jadlowsky J, Harding CV, Weinberg A, Sieg SF.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18631-5. Epub 2007 Nov 15.


Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.

Jo EK, Yang CS, Choi CH, Harding CV.

Cell Microbiol. 2007 May;9(5):1087-98. Epub 2007 Mar 13. Review.


Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.

Pecora ND, Gehring AJ, Canaday DH, Boom WH, Harding CV.

J Immunol. 2006 Jul 1;177(1):422-9.


Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.

Gehring AJ, Dobos KM, Belisle JT, Harding CV, Boom WH.

J Immunol. 2004 Aug 15;173(4):2660-8.

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