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What can mathematical modelling say about CHO metabolism and protein glycosylation?
Galleguillos SN, Ruckerbauer D, Gerstl MP, Borth N, Hanscho M, Zanghellini J. Galleguillos SN, et al. Among authors: hanscho m. Comput Struct Biotechnol J. 2017 Jan 28;15:212-221. doi: 10.1016/j.csbj.2017.01.005. eCollection 2017. Comput Struct Biotechnol J. 2017. PMID: 28228925 Free PMC article. Review.
Inclusion of maintenance energy improves the intracellular flux predictions of CHO.
Széliová D, Štor J, Thiel I, Weinguny M, Hanscho M, Lhota G, Borth N, Zanghellini J, Ruckerbauer DE, Rocha I. Széliová D, et al. Among authors: hanscho m. PLoS Comput Biol. 2021 Jun 11;17(6):e1009022. doi: 10.1371/journal.pcbi.1009022. eCollection 2021 Jun. PLoS Comput Biol. 2021. PMID: 34115746 Free PMC article.
Designing Optimized Production Hosts by Metabolic Modeling.
Jungreuthmayer C, Gerstl MP, Peña Navarro DA, Hanscho M, Ruckerbauer DE, Zanghellini J. Jungreuthmayer C, et al. Among authors: hanscho m. Methods Mol Biol. 2018;1716:371-387. doi: 10.1007/978-1-4939-7528-0_17. Methods Mol Biol. 2018. PMID: 29222763
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.
Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, Wulff T, Arnsdorf J, Li S, Lee JS, Paglia G, Loira N, Spahn PN, Pedersen LE, Gutierrez JM, King ZA, Lund AM, Nagarajan H, Thomas A, Abdel-Haleem AM, Zanghellini J, Kildegaard HF, Voldborg BG, Gerdtzen ZP, Betenbaugh MJ, Palsson BO, Andersen MR, Nielsen LK, Borth N, Lee DY, Lewis NE. Hefzi H, et al. Among authors: hanscho m. Cell Syst. 2016 Nov 23;3(5):434-443.e8. doi: 10.1016/j.cels.2016.10.020. Cell Syst. 2016. PMID: 27883890 Free PMC article.
Recon 2.2: from reconstruction to model of human metabolism.
Swainston N, Smallbone K, Hefzi H, Dobson PD, Brewer J, Hanscho M, Zielinski DC, Ang KS, Gardiner NJ, Gutierrez JM, Kyriakopoulos S, Lakshmanan M, Li S, Liu JK, Martínez VS, Orellana CA, Quek LE, Thomas A, Zanghellini J, Borth N, Lee DY, Nielsen LK, Kell DB, Lewis NE, Mendes P. Swainston N, et al. Among authors: hanscho m. Metabolomics. 2016;12:109. doi: 10.1007/s11306-016-1051-4. Epub 2016 Jun 7. Metabolomics. 2016. PMID: 27358602 Free PMC article.
What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines.
Széliová D, Ruckerbauer DE, Galleguillos SN, Petersen LB, Natter K, Hanscho M, Troyer C, Causon T, Schoeny H, Christensen HB, Lee DY, Lewis NE, Koellensperger G, Hann S, Nielsen LK, Borth N, Zanghellini J. Széliová D, et al. Among authors: hanscho m. Metab Eng. 2020 Sep;61:288-300. doi: 10.1016/j.ymben.2020.06.002. Epub 2020 Jun 30. Metab Eng. 2020. PMID: 32619503 Free article.
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