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Items: 1 to 20 of 124

1.

A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.

Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J.

Cell Rep. 2018 Sep 18;24(12):3312-3323.e5. doi: 10.1016/j.celrep.2018.08.061.

2.

Editorial: Chemokines - beyond chemotaxis.

Proudfoot AE, Handel TM, Graham G.

Cytokine. 2018 Sep;109:1. doi: 10.1016/j.cyto.2018.04.036. Epub 2018 Jun 1. No abstract available.

PMID:
29861383
3.

Intracellular Receptor Modulation: Novel Approach to Target GPCRs.

Ortiz Zacarías NV, Lenselink EB, IJzerman AP, Handel TM, Heitman LH.

Trends Pharmacol Sci. 2018 Jun;39(6):547-559. doi: 10.1016/j.tips.2018.03.002. Epub 2018 Apr 10. Review.

PMID:
29653834
4.

Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System.

Proudfoot AEI, Johnson Z, Bonvin P, Handel TM.

Pharmaceuticals (Basel). 2017 Aug 9;10(3). pii: E70. doi: 10.3390/ph10030070. Review.

5.

Heparan Sulfate Microarray Reveals That Heparan Sulfate-Protein Binding Exhibits Different Ligand Requirements.

Zong C, Venot A, Li X, Lu W, Xiao W, Wilkes JL, Salanga CL, Handel TM, Wang L, Wolfert MA, Boons GJ.

J Am Chem Soc. 2017 Jul 19;139(28):9534-9543. doi: 10.1021/jacs.7b01399. Epub 2017 Jul 7.

6.

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.

Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM.

Immunity. 2017 Jun 20;46(6):1005-1017.e5. doi: 10.1016/j.immuni.2017.05.002.

7.

What Do Structures Tell Us About Chemokine Receptor Function and Antagonism?

Kufareva I, Gustavsson M, Zheng Y, Stephens BS, Handel TM.

Annu Rev Biophys. 2017 May 22;46:175-198. doi: 10.1146/annurev-biophys-051013-022942. Review.

8.

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization.

Dyer DP, Migliorini E, Salanga CL, Thakar D, Handel TM, Richter RP.

Open Biol. 2017 Jan;7(1). pii: 160286. doi: 10.1098/rsob.160286.

9.

Structural basis of ligand interaction with atypical chemokine receptor 3.

Gustavsson M, Wang L, van Gils N, Stephens BS, Zhang P, Schall TJ, Yang S, Abagyan R, Chance MR, Kufareva I, Handel TM.

Nat Commun. 2017 Jan 18;8:14135. doi: 10.1038/ncomms14135.

10.

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM.

Nature. 2016 Dec 15;540(7633):458-461. doi: 10.1038/nature20605. Epub 2016 Dec 7.

11.

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.

Wescott MP, Kufareva I, Paes C, Goodman JR, Thaker Y, Puffer BA, Berdougo E, Rucker JB, Handel TM, Doranz BJ.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9928-33. doi: 10.1073/pnas.1601278113. Epub 2016 Aug 19.

12.

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

Dyer DP, Salanga CL, Johns SC, Valdambrini E, Fuster MM, Milner CM, Day AJ, Handel TM.

J Biol Chem. 2016 Jun 10;291(24):12627-40. doi: 10.1074/jbc.M116.720953. Epub 2016 Apr 4.

13.

Preface.

Handel TM.

Methods Enzymol. 2016;570:xxi-xxii. doi: 10.1016/S0076-6879(16)00083-5. No abstract available.

PMID:
26921963
14.

Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes.

Kufareva I, Gustavsson M, Holden LG, Qin L, Zheng Y, Handel TM.

Methods Enzymol. 2016;570:389-420. doi: 10.1016/bs.mie.2015.12.001. Epub 2016 Jan 13.

15.

Examining Roles of Glycans in Chemokine-Mediated Dendritic-Endothelial Cell Interactions.

Yin X, Johns SC, El Ghazal R, Salanga CL, Handel TM, Fuster MM.

Methods Enzymol. 2016;570:335-55. doi: 10.1016/bs.mie.2015.09.017. Epub 2015 Nov 14.

PMID:
26921954
16.

Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies.

Gustavsson M, Zheng Y, Handel TM.

Methods Enzymol. 2016;570:233-60. doi: 10.1016/bs.mie.2015.10.003. Epub 2015 Dec 14.

17.

Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer.

Fox JC, Tyler RC, Peterson FC, Dyer DP, Zhang F, Linhardt RJ, Handel TM, Volkman BF.

Biochemistry. 2016 Mar 1;55(8):1214-25. doi: 10.1021/acs.biochem.5b01329. Epub 2016 Feb 17.

18.

The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.

Dyer DP, Salanga CL, Volkman BF, Kawamura T, Handel TM.

Glycobiology. 2016 Mar;26(3):312-26. doi: 10.1093/glycob/cwv100. Epub 2015 Nov 17.

19.

Cytokines and growth factors cross-link heparan sulfate.

Migliorini E, Thakar D, Kühnle J, Sadir R, Dyer DP, Li Y, Sun C, Volkman BF, Handel TM, Coche-Guerente L, Fernig DG, Lortat-Jacob H, Richter RP.

Open Biol. 2015 Aug;5(8). pii: 150046. doi: 10.1098/rsob.150046.

20.

Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs.

Kufareva I, Handel TM, Abagyan R.

Methods Mol Biol. 2015;1335:295-311. doi: 10.1007/978-1-4939-2914-6_19.

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