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Reumatologia. 2016;54(2):61-6. doi: 10.5114/reum.2016.60214. Epub 2016 Jun 3.

Do we still need renal biopsy in lupus nephritis?

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Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain.


The natural course of systemic lupus erythematosus (SLE) is characterized by periods of disease activity and remissions. Prolonged disease activity results in cumulative organ damage. Lupus nephritis is one of the most common and devastating manifestations of SLE. In the era of changing therapy to less toxic regimens, some authors have stated that if mycophenolate mofetil can be used for the induction and maintenance treatment in all histological classes of lupus nephritis, renal biopsy can be omitted. This article aims to answer the question of what brings the bigger risk: renal biopsy or its abandonment.


lupus nephritis; renal biopsy; repeated renal biopsy

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