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Br J Haematol. 2012 Jun;157(6):742-6. doi: 10.1111/j.1365-2141.2012.09122.x. Epub 2012 Apr 26.

Haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases: analysis of UK outcomes from the British Society of Blood and Marrow Transplantation (BSBMT) data registry 1997-2009.

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1
Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust and Department of Oncology, University of Sheffield, Sheffield, UK. john.snowden@sth.nhs.uk

Abstract

The British Society of Blood and Marrow Transplantation Data Registry was used to analyse outcomes of haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases (SADs) from 1997 to 2009. 55 autologous and 15 allogeneic HSCT were registered (0ยท22% of overall UK HSCT activity). Sustained responses were observed following HSCT, although toxicity was significant. This is the first reported national analysis of long-term outcomes of HSCT in SADs, and should be viewed in the context of translational and developmental phases of HSCT in poor prognosis and refractory SADs. Treatment of poor-risk but reversible SADs with adequate fitness for HSCT in accordance with current guidelines is warranted.

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