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Int J Mol Sci. 2015 Nov 19;16(11):27677-706. doi: 10.3390/ijms161126056.

Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine.

Author information

1
Institute of Pharmacy, Pharmaceutical Technology, Leipzig University, Eilenburger Str. 15a, D-04317 Leipzig, Germany. mhacker@uni-leipzig.de.
2
Institute of Pharmacy, Pharmaceutical Technology, Leipzig University, Eilenburger Str. 15a, D-04317 Leipzig, Germany. hn69sohi@studserv.uni-leipzig.de.

Abstract

Contemporary biomaterials are expected to provide tailored mechanical, biological and structural cues to encapsulated or invading cells in regenerative applications. In addition, the degradative properties of the material also have to be adjustable to the desired application. Oligo- or polymeric building blocks that can be further cross-linked into hydrogel networks, here addressed as macromers, appear as the prime option to assemble gels with the necessary degrees of freedom in the adjustment of the mentioned key parameters. Recent developments in the design of multi-functional macromers with two or more chemically different types of functionalities are summarized and discussed in this review illustrating recent trends in the development of advanced hydrogel building blocks for regenerative applications.

KEYWORDS:

N-isopropylacrylamide; chemical cross-linking; click chemistry; copolymer; functional groups; macromer; macromonomer; physical gelation; smart hydrogel

PMID:
26610468
PMCID:
PMC4661914
DOI:
10.3390/ijms161126056
[Indexed for MEDLINE]
Free PMC Article

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