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Items: 1 to 20 of 141


Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.

Hammers DW, Sleeper MM, Forbes SC, Coker CC, Jirousek MR, Zimmer M, Walter GA, Sweeney HL.

JCI Insight. 2016 Dec 22;1(21):e90341. doi: 10.1172/jci.insight.90341.


Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.

Milewicz DM, Trybus KM, Guo DC, Sweeney HL, Regalado E, Kamm K, Stull JT.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):26-34. doi: 10.1161/ATVBAHA.116.303229. Erratum in: Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):e12.


Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy.

Liu M, Hammers DW, Barton ER, Sweeney HL.

PLoS One. 2016 Nov 21;11(11):e0166803. doi: 10.1371/journal.pone.0166803.


How Myosin Generates Force on Actin Filaments.

Houdusse A, Sweeney HL.

Trends Biochem Sci. 2016 Dec;41(12):989-997. doi: 10.1016/j.tibs.2016.09.006. Review.


The myosin X motor is optimized for movement on actin bundles.

Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, Sweeney HL, Houdusse A.

Nat Commun. 2016 Sep 1;7:12456. doi: 10.1038/ncomms12456.


Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.

Hammers DW, Sleeper MM, Forbes SC, Shima A, Walter GA, Sweeney HL.

J Am Heart Assoc. 2016 Aug 9;5(8). pii: e003911. doi: 10.1161/JAHA.116.003911.


Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.

Chang AN, Mahajan P, Knapp S, Barton H, Sweeney HL, Kamm KE, Stull JT.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3824-33. doi: 10.1073/pnas.1600633113.


Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype.

Capote J, Kramerova I, Martinez L, Vetrone S, Barton ER, Sweeney HL, Miceli MC, Spencer MJ.

J Cell Biol. 2016 Apr 25;213(2):275-88. doi: 10.1083/jcb.201510086.


Force-producing ADP state of myosin bound to actin.

Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse AM, Schröder RR.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1844-52. doi: 10.1073/pnas.1516598113.


Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish.

Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M.

Dis Model Mech. 2016 May 1;9(5):529-40. doi: 10.1242/dmm.023309.


Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort.

Willcocks RJ, Rooney WD, Triplett WT, Forbes SC, Lott DJ, Senesac CR, Daniels MJ, Wang DJ, Harrington AT, Tennekoon GI, Russman BS, Finanger EL, Byrne BJ, Finkel RS, Walter GA, Sweeney HL, Vandenborne K.

Ann Neurol. 2016 Apr;79(4):535-47. doi: 10.1002/ana.24599.


Increased collagen cross-linking is a signature of dystrophin-deficient muscle.

Smith LR, Hammers DW, Sweeney HL, Barton ER.

Muscle Nerve. 2016 Jun;54(1):71-8. doi: 10.1002/mus.24998.


How a patient advocacy group developed the first proposed draft guidance document for industry for submission to the U.S. Food and Drug Administration.

Furlong P, Bridges JF, Charnas L, Fallon JR, Fischer R, Flanigan KM, Franson TR, Gulati N, McDonald C, Peay H, Sweeney HL.

Orphanet J Rare Dis. 2015 Jun 24;10:82. doi: 10.1186/s13023-015-0281-2.


Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements.

Vohra RS, Lott D, Mathur S, Senesac C, Deol J, Germain S, Bendixen R, Forbes SC, Sweeney HL, Walter GA, Vandenborne K.

PLoS One. 2015 Jun 23;10(6):e0128915. doi: 10.1371/journal.pone.0128915.


Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy.

Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini D, Sweeney HL, D Armiento J, Ali ZA, Schulze PC, George I.

Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H459-70. doi: 10.1152/ajpheart.00056.2015.


Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy.

Hathout Y, Brody E, Clemens PR, Cripe L, DeLisle RK, Furlong P, Gordish-Dressman H, Hache L, Henricson E, Hoffman EP, Kobayashi YM, Lorts A, Mah JK, McDonald C, Mehler B, Nelson S, Nikrad M, Singer B, Steele F, Sterling D, Sweeney HL, Williams S, Gold L.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7153-8. doi: 10.1073/pnas.1507719112.


How actin initiates the motor activity of Myosin.

Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A.

Dev Cell. 2015 May 26;33(4):401-12. doi: 10.1016/j.devcel.2015.03.025.


Myosin VI deafness mutation prevents the initiation of processive runs on actin.

Pylypenko O, Song L, Shima A, Yang Z, Houdusse AM, Sweeney HL.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1201-9. doi: 10.1073/pnas.1420989112.


Early loss of ambulation is not a representative clinical feature in Duchenne muscular dystrophy dogs: remarks on the article of Barthélémy et al.

Duan D, Hakim CH, Ambrosio CE, Smith BF, Sweeney HL.

Dis Model Mech. 2015 Mar;8(3):193-4. doi: 10.1242/dmm.019216. No abstract available.


Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy.

Castillero E, Akashi H, Wang C, Najjar M, Ji R, Kennel PJ, Sweeney HL, Schulze PC, George I.

Biochem Biophys Res Commun. 2015 Jan 30;457(1):106-11. doi: 10.1016/j.bbrc.2014.12.057.

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