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Items: 1 to 20 of 258

1.

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP.

Aging Cell. 2018 Dec 10:e12845. doi: 10.1111/acel.12845. [Epub ahead of print]

2.

A Functional Immune System Is Required For The Systemic Genotoxic Effects Of Localised Irradiation.

Lobachevsky PN, Ventura J, Giannakandropoulou L, Forrester H, Palazzolo JS, Haynes NM, Stevenson AW, Hall CJ, Mason J, Pollakis G, Pateras IS, Gorgoulis V, Terzoudi GI, Hamilton JA, Sprung CN, Georgakilas AG, Martin OA.

Int J Radiat Oncol Biol Phys. 2018 Dec 6. pii: S0360-3016(18)34068-9. doi: 10.1016/j.ijrobp.2018.11.066. [Epub ahead of print]

PMID:
30529375
3.

Cura"x"ing Cancer and Beyond.

Gorgoulis VG, Kotsinas A.

Bioessays. 2019 Jan;41(1):e1800223. doi: 10.1002/bies.201800223. Epub 2018 Dec 3. No abstract available.

PMID:
30507004
4.

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Cooks T, Theodorou SD, Paparouna E, Rizou SV, Myrianthopoulos V, Gorgoulis VG, Pateras IS.

Histol Histopathol. 2018 Nov 27:18069. doi: 10.14670/HH-18-069. [Epub ahead of print] Review.

PMID:
30480312
5.

A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:119-138. doi: 10.1007/978-1-4939-8931-7_12.

PMID:
30474845
6.

LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.

Furth N, Pateras IS, Rotkopf R, Vlachou V, Rivkin I, Schmitt I, Bakaev D, Gershoni A, Ainbinder E, Leshkowitz D, Johnson RL, Gorgoulis VG, Oren M, Aylon Y.

Life Sci Alliance. 2018 Oct 30;1(5):e201800171. doi: 10.26508/lsa.201800171. eCollection 2018 Oct.

7.

Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics.

Lallo A, Gulati S, Schenk MW, Khandelwal G, Berglund UW, Pateras IS, Chester CPE, Pham TM, Kalderen C, Frese KK, Gorgoulis VG, Miller C, Blackhall F, Helleday T, Dive C.

Br J Pharmacol. 2019 Feb;176(3):436-450. doi: 10.1111/bph.14542. Epub 2018 Dec 13.

PMID:
30427531
8.

Ageing, Cellular Senescence and Neurodegenerative Disease.

Kritsilis M, V Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2937. doi: 10.3390/ijms19102937. Review.

9.

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A.

Cell. 2018 Aug 23;174(5):1325-1326. doi: 10.1016/j.cell.2018.08.015. No abstract available.

PMID:
30142346
10.

Senescence and senotherapeutics: a new field in cancer therapy.

Myrianthopoulos V, Evangelou K, Vasileiou PVS, Cooks T, Vassilakopoulos TP, Pangalis GA, Kouloukoussa M, Kittas C, Georgakilas AG, Gorgoulis VG.

Pharmacol Ther. 2019 Jan;193:31-49. doi: 10.1016/j.pharmthera.2018.08.006. Epub 2018 Aug 16. Review.

11.

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.

Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S.

J Pathol. 2018 Oct;246(2):134-140. doi: 10.1002/path.5128. Epub 2018 Aug 21.

PMID:
29952003
12.

MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B.

Pefani DE, Tognoli ML, Pirincci Ercan D, Gorgoulis V, O'Neill E.

EMBO J. 2018 Aug 1;37(15). pii: e98760. doi: 10.15252/embj.201798760. Epub 2018 May 22.

13.

Targeting Tie-2/angiopoietin axis in experimental mesothelioma confers differential responses and raises predictive implications.

Magkouta S, Pappas A, Pateras IS, Kollintza A, Moschos C, Vazakidou ME, Karavana V, Gorgoulis VG, Kalomenidis I.

Oncotarget. 2018 Apr 24;9(31):21783-21796. doi: 10.18632/oncotarget.25004. eCollection 2018 Apr 24.

14.

Integrating the DNA damage and protein stress responses during cancer development and treatment.

Gorgoulis VG, Pefani DE, Pateras IS, Trougakos IP.

J Pathol. 2018 Sep;246(1):12-40. doi: 10.1002/path.5097. Epub 2018 Jul 19. Review.

15.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

16.

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution.

Barbouti A, Evangelou K, Pateras IS, Papoudou-Bai A, Patereli A, Stefanaki K, Rontogianni D, Muñoz-Espín D, Kanavaros P, Gorgoulis VG.

Mech Ageing Dev. 2019 Jan;177:88-90. doi: 10.1016/j.mad.2018.02.005. Epub 2018 Feb 25.

PMID:
29490231
17.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC.

Nat Commun. 2018 Feb 22;9(1):771. doi: 10.1038/s41467-018-03224-w.

18.

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V.

Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18.

PMID:
29343849
19.

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.

Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O'Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J, Gorgoulis VG.

BMC Genomics. 2018 Jan 10;19(1):37. doi: 10.1186/s12864-017-4375-1.

20.

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses.

Ventura J, Lobachevsky PN, Palazzolo JS, Forrester H, Haynes NM, Ivashkevich A, Stevenson AW, Hall CJ, Ntargaras A, Kotsaris V, Pollakis GC, Potsi G, Skordylis K, Terzoudi G, Pateras IS, Gorgoulis VG, Georgakilas AG, Sprung CN, Martin OA.

Cancer Res. 2017 Nov 15;77(22):6389-6399. doi: 10.1158/0008-5472.CAN-17-1066. Epub 2017 Nov 7.

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