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Bioorg Med Chem Lett. 2010 May 1;20(9):2718-21. doi: 10.1016/j.bmcl.2010.03.079. Epub 2010 Mar 25.

Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents.

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Laboratory of GlycoNanotechnology, CIC biomaGUNE/CIBER-BBN, P degrees Miramón 182, San Sebastián E-20009, Spain.


Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on approximately 2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems.

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