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Oxidative Modifications of Mitochondrial Complex II are associated with insulin resistance of visceral fat in obesity.

Ngo DT, Sverdlov AL, Karki S, Macartney-Coxson D, Stubbs RS, Farb MG, Carmine B, Hess DT, Colucci WS, Gokce N.

Am J Physiol Endocrinol Metab. 2018 Dec 21. doi: 10.1152/ajpendo.00227.2018. [Epub ahead of print]


Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation.

Zuriaga MA, Fuster JJ, Farb MG, MacLauchlan S, Bretón-Romero R, Karki S, Hess DT, Apovian CM, Hamburg NM, Gokce N, Walsh K.

Sci Rep. 2017 Dec 11;7(1):17326. doi: 10.1038/s41598-017-17509-5.


Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy.

Farb MG, Park SY, Karki S, Gokce N.

J Vis Exp. 2017 Sep 29;(127). doi: 10.3791/56079.


Humans and Mice Display Opposing Patterns of "Browning" Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots.

Zuriaga MA, Fuster JJ, Gokce N, Walsh K.

Front Cardiovasc Med. 2017 May 5;4:27. doi: 10.3389/fcvm.2017.00027. eCollection 2017.


WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans.

Karki S, Ngo DTM, Farb MG, Park SY, Saggese SM, Hamburg NM, Carmine B, Hess DT, Walsh K, Gokce N.

Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H200-H206. doi: 10.1152/ajpheart.00776.2016. Epub 2017 Apr 14.


WNT5A-JNK regulation of vascular insulin resistance in human obesity.

Farb MG, Karki S, Park SY, Saggese SM, Carmine B, Hess DT, Apovian C, Fetterman JL, Bretón-Romero R, Hamburg NM, Fuster JJ, Zuriaga MA, Walsh K, Gokce N.

Vasc Med. 2016 Dec;21(6):489-496. Epub 2016 Sep 28.


Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.

Fuster JJ, Ouchi N, Gokce N, Walsh K.

Circ Res. 2016 May 27;118(11):1786-807. doi: 10.1161/CIRCRESAHA.115.306885. Review.


Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease.

Fetterman JL, Holbrook M, Westbrook DG, Brown JA, Feeley KP, Bretón-Romero R, Linder EA, Berk BD, Weisbrod RM, Widlansky ME, Gokce N, Ballinger SW, Hamburg NM.

Cardiovasc Diabetol. 2016 Mar 31;15:53. doi: 10.1186/s12933-016-0372-y.


Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling.

Fetterman JL, Holbrook M, Flint N, Feng B, Bretón-Romero R, Linder EA, Berk BD, Duess MA, Farb MG, Gokce N, Shirihai OS, Hamburg NM, Vita JA.

Atherosclerosis. 2016 Apr;247:207-17. doi: 10.1016/j.atherosclerosis.2016.01.043. Epub 2016 Feb 13.


Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a-JNK Signaling.

Bretón-Romero R, Feng B, Holbrook M, Farb MG, Fetterman JL, Linder EA, Berk BD, Masaki N, Weisbrod RM, Inagaki E, Gokce N, Fuster JJ, Walsh K, Hamburg NM.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):561-9. doi: 10.1161/ATVBAHA.115.306578. Epub 2016 Jan 21.


Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults.

Tampakakis E, Tabit CE, Holbrook M, Linder EA, Berk BD, Frame AA, Bretón-Romero R, Fetterman JL, Gokce N, Vita JA, Hamburg NM.

J Am Heart Assoc. 2016 Jan 11;5(1). pii: e002574. doi: 10.1161/JAHA.115.002574.


Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans.

Karki S, Farb MG, Myers S, Apovian C, Hess DT, Gokce N.

Mediators Inflamm. 2015;2015:106237. doi: 10.1155/2015/106237. Epub 2015 Nov 18.


Preclinical Systolic and Diastolic Dysfunctions in Metabolically Healthy and Unhealthy Obese Individuals.

Wang YC, Liang CS, Gopal DM, Ayalon N, Donohue C, Santhanakrishnan R, Sandhu H, Perez AJ, Downing J, Gokce N, Colucci WS, Ho JE.

Circ Heart Fail. 2015 Sep;8(5):897-904. doi: 10.1161/CIRCHEARTFAILURE.114.002026. Epub 2015 Jul 14.


Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity.

Karki S, Farb MG, Ngo DT, Myers S, Puri V, Hamburg NM, Carmine B, Hess DT, Gokce N.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1498-506. doi: 10.1161/ATVBAHA.114.305139. Epub 2015 Apr 23.


Visceral adiposopathy: a vascular perspective.

Farb MG, Gokce N.

Horm Mol Biol Clin Investig. 2015 Feb;21(2):125-36. doi: 10.1515/hmbci-2014-0047. Review.


Impaired right ventricular hemodynamics indicate preclinical pulmonary hypertension in patients with metabolic syndrome.

Gopal DM, Santhanakrishnan R, Wang YC, Ayalon N, Donohue C, Rahban Y, Perez AJ, Downing J, Liang CS, Gokce N, Colucci WS, Ho JE.

J Am Heart Assoc. 2015 Mar 10;4(3):e001597. doi: 10.1161/JAHA.114.001597.


Epicardial adipose tissue: a benign consequence of obesity?

Ngo DT, Gokce N.

Circ Cardiovasc Imaging. 2015 Mar;8(3). pii: e003156. doi: 10.1161/CIRCIMAGING.115.003156. No abstract available.


An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease.

Kikuchi R, Nakamura K, MacLauchlan S, Ngo DT, Shimizu I, Fuster JJ, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi TP, Matsushita T, Murohara T, Gokce N, Bates DO, Hamburg NM, Walsh K.

Nat Med. 2014 Dec;20(12):1464-71. doi: 10.1038/nm.3703. Epub 2014 Nov 2.


Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion.

Fuster JJ, Zuriaga MA, Ngo DT, Farb MG, Aprahamian T, Yamaguchi TP, Gokce N, Walsh K.

Diabetes. 2015 Apr;64(4):1235-48. doi: 10.2337/db14-1164. Epub 2014 Oct 28.


Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity.

Ngo DT, Farb MG, Kikuchi R, Karki S, Tiwari S, Bigornia SJ, Bates DO, LaValley MP, Hamburg NM, Vita JA, Hess DT, Walsh K, Gokce N.

Circulation. 2014 Sep 23;130(13):1072-80. doi: 10.1161/CIRCULATIONAHA.113.008171. Epub 2014 Aug 12.

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