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Int J Clin Exp Med. 2015 Sep 15;8(9):16266-72. eCollection 2015.

Glycyrrhizin combined with acitretin improve clinical symptom of psoriasis via reducing Th17 cell differentiation and related serum cytokine concentrations.

Author information

1
Department of Dermatology, Shandong Provincial Hospital for Skin Diseases, Shandong University No. 27397, Jing Shi Road, Jinan 250022, Shandong, China ; Department of Dermatology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University No. 3002, Sun Gang Xi Road, Shenzhen 518035, Guangdong, China.
2
Department of Dermatology, Shandong Provincial Hospital for Skin Diseases, Shandong University No. 27397, Jing Shi Road, Jinan 250022, Shandong, China.

Abstract

OBJECTIVE:

To evaluate the effect of compound glycyrrhizin in combination with acitretin on Th17 cell and related cytokines expressions in patients with psoriasis.

METHODS:

A total of 100 patients with psoriasis were enrolled in our study and randomized into an acitretin (Aci) group (n = 50) and a compound glycyrrhizin/acitretin combined treatment (Aci + Glyc) group (n = 50). Both groups were medicated with 3 × 10 mg acitretin per day for 8 weeks but the (Aci + Glyc) group received additionally 3 × 75 mg compound glycyrrhizin every day. A total of 50 healthy individuals were selected as the control group. The peripheral blood Th17 cell percentage as well as the IL-6, IL-17, IL-22 and TGF-β serum concentrations in addition to PASI scores were determined before and after medications.

RESULTS:

The Th17 cell percentages and the serum concentrations of IL-6, IL-17, IL-22 and TGF-β in the Aci and Aci + Glyc groups were significantly higher than those in the control group before treatments (P < 0.05) and were significantly declined after the treatments (P < 0.05), but to a higher extend in the Aci + Glyc group (P < 0.05). The clinical treatment effective rates in the Aci group and the Aci + Glyc group were 76.0% and 90.0% (P < 0.05) compared to invalid events after treatments.

CONCLUSIONS:

Compound glycyrrhizin in combination with acitretin can improve the clinical efficacy significantly when compared with of the solely acitretin medication for psoriasis treatments via down regulating Th17 cell differentiation.

KEYWORDS:

Psoriasis; Th17; acitretin; compound glycyrrhizin

PMID:
26629143
PMCID:
PMC4659031

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