Send to

Choose Destination

See 1 citation found by title matching your search:

JAMA Oncol. 2018 Sep 1;4(9):1221-1227. doi: 10.1001/jamaoncol.2018.2128.

Global Burden of Multiple Myeloma: A Systematic Analysis for the Global Burden of Disease Study 2016.

Author information

Division of Medical Oncology, University of Washington, Seattle.
Institute for Health Metrics and Evaluation, University of Washington, Seattle.
University of Belgrade, Belgrade, Serbia.
Aden University, Aden, Yemen.
University of São Paolo, São Paolo, Brazil.
Accamargo Cancer Center, São Paolo, Brazil.
International Prevention Research Institute, Ecully, France.
West Virginia Bureau for Public Health, Charleston.
Albert Einstein College of Medicine, Bronx, New York.
University of Kragujevac, Kragujevac, Serbia.
Center for Health Trends and Forecasts, University of Washington, Seattle.
Department of Community Medicine, Public Health and Family Medicine, Jordan University of Science and Technology, Irbid, Jordan.
University of Haifa, Haifa, Israel.
Postgraduate Institute of Medical Education and Research, Candigarh, India.
University of Milano-Bicocca, Milan, Italy.
Institute for Global Health Innovations, Duy Tan University, Danang, Vietnam.
University Medical Center, Gronigen, the Netherlands.
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Haramaya University, Haramaya, Ethiopia.
Johns Hopkins University, Baltimore, Maryland.
Hanoi Medical University, Hanoi, Vietnam.
Department of Internal Medicine, Federal Teaching Hospital, Abakaliki, Nigeria.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo.
Division of Hematology, University of Washington, Seattle.



Multiple myeloma (MM) is a plasma cell neoplasm with substantial morbidity and mortality. A comprehensive description of the global burden of MM is needed to help direct health policy, resource allocation, research, and patient care.


To describe the burden of MM and the availability of effective therapies for 21 world regions and 195 countries and territories from 1990 to 2016.

Design and Setting:

We report incidence, mortality, and disability-adjusted life-year (DALY) estimates from the Global Burden of Disease 2016 study. Data sources include vital registration system, cancer registry, drug availability, and survey data for stem cell transplant rates. We analyzed the contribution of aging, population growth, and changes in incidence rates to the overall change in incident cases from 1990 to 2016 globally, by sociodemographic index (SDI) and by region. We collected data on approval of lenalidomide and bortezomib worldwide.

Main Outcomes and Measures:

Multiple myeloma mortality; incidence; years lived with disabilities; years of life lost; and DALYs by age, sex, country, and year.


Worldwide in 2016 there were 138 509 (95% uncertainty interval [UI], 121 000-155 480) incident cases of MM with an age-standardized incidence rate (ASIR) of 2.1 per 100 000 persons (95% UI, 1.8-2.3). Incident cases from 1990 to 2016 increased by 126% globally and by 106% to 192% for all SDI quintiles. The 3 world regions with the highest ASIR of MM were Australasia, North America, and Western Europe. Multiple myeloma caused 2.1 million (95% UI, 1.9-2.3 million) DALYs globally in 2016. Stem cell transplantation is routinely available in higher-income countries but is lacking in sub-Saharan Africa and parts of the Middle East. In 2016, lenalidomide and bortezomib had been approved in 73 and 103 countries, respectively.

Conclusions and Relevance:

Incidence of MM is highly variable among countries but has increased uniformly since 1990, with the largest increase in middle and low-middle SDI countries. Access to effective care is very limited in many countries of low socioeconomic development, particularly in sub-Saharan Africa. Global health policy priorities for MM are to improve diagnostic and treatment capacity in low and middle income countries and to ensure affordability of effective medications for every patient. Research priorities are to elucidate underlying etiological factors explaining the heterogeneity in myeloma incidence.

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center