Send to

Choose Destination

See 1 citation found by title matching your search:

Eur J Nucl Med Mol Imaging. 2017 Dec;44(13):2274-2279. doi: 10.1007/s00259-017-3774-5. Epub 2017 Jul 24.

Giant-cell arteritis: concordance study between aortic CT angiography and FDG-PET/CT in detection of large-vessel involvement.

Author information

Department of Internal Medicine, Caen University Hospital, Avenue de la Côte de Nacre, 14000, Caen, France.
Department of Internal Medicine, Caen University Hospital, Avenue de la Côte de Nacre, 14000, Caen, France.
Department of Internal Medicine, Limoges University Hospital, Limoges, France.
Department of Internal Medicine, Lille University Hospital, Lille, France.
Department of Nuclear Medicine, Caen University Hospital, Caen, France.
INSERM U1086 "ANTICIPE", François Baclesse Cancer Centre, Caen, France.
Normandy University, EA4650, Caen, France.



The purpose of our study was to assess the concordance of aortic CT angiography (CTA) and FDG-PET/CT in the detection of large-vessel involvement at diagnosis in patients with giant-cell arteritis (GCA).


We created a multicenter cohort of patients with GCA diagnosed between 2010 and 2015, and who underwent both FDG-PET/CT and aortic CTA before or in the first ten days following treatment introduction. Eight vascular segments were studied on each procedure. We calculated concordance between both imaging techniques in a per-patient and a per-segment analysis, using Cohen's kappa concordance index.


We included 28 patients (21/7 women/men, median age 67 [56-82]). Nineteen patients had large-vessel involvement on PET/CT and 18 of these patients also presented positive findings on CTA. In a per-segment analysis, a median of 5 [1-7] and 3 [1-6] vascular territories were involved on positive PET/CT and CTA, respectively (p = 0.03). In qualitative analysis, i.e., positivity of the procedure suggesting a large-vessel involvement, the concordance rate between both procedures was 0.85 [0.64-1]. In quantitative analysis, i.e., per-segment analysis in both procedures, the global concordance rate was 0.64 [0.54-0.75]. Using FDG-PET/CT as a reference, CTA showed excellent sensitivity (95%) and specificity (100%) in a per-patient analysis. In a per-segment analysis, sensitivity and specificity were 61% and 97.9%, respectively.


CTA and FDG-PET/CT were both able to detect large-vessel involvement in GCA with comparable results in a per-patient analysis. However, PET/CT showed higher performance in a per-segment analysis, especially in the detection of inflammation of the aorta's branches.


18FDG-pet/Ct; CT angiography; Giant-cell arteritis; Large-vessel vasculitis

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center