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Appl Physiol Nutr Metab. 2019 Feb 22. doi: 10.1139/apnm-2018-0549. [Epub ahead of print]

Effect of dairy and non-dairy snacks on postprandial blood glucose regulation in 9-14 year old children.

Author information

1
Mount Saint Vincent University , Department of Applied Nutrition , 166 Bedford Hwy , Halifax, Nova Scotia, Canada , B3M 2J6 ; bjg223@cornell.edu.
2
Mount Saint Vincent University, 3684, Department of Applied Human Nutrition, Halifax, Nova Scotia, Canada ; meg369@cornell.edu.
3
Mount Saint Vincent University, 3684, Department of Applied Human Nutrition, Halifax, Nova Scotia, Canada ; Athena.cy.li@gmail.com.
4
Mount Saint Vincent University, 3684, Department of Child and Youth Study, Halifax, Nova Scotia, Canada ; fernando.nunes@msvu.ca.
5
Dalhousie University, 3688, Department of Physiology and Biophysics , Halifax, Nova Scotia, Canada.
6
IWK Health Centre, 3682, Department of Obstetrics and Gynaecology, Halifax, Nova Scotia, Canada ; younes.anini@dal.ca.
7
Mount Saint Vincent Unviersity , Department of Applied Human Nutrition , 166 Bedford Highway , Halifax, Nova Scotia, Canada , B3M 2J6 ; Theresa.Glanville@msvu.ca.
8
Ryerson University, School of Nutrition, Faculty of Community Services , 350 Victoria Street , Toronto, Ontario, Canada , M5B 2K3 ; nick.bellissimo@ryerson.ca.
9
Hospital for Sick Children, 7979, Endocrinology , 555 University Ave , Toronto, Ontario, Canada , M5G 1X8 ; jill.hamilton@sickkids.ca.
10
University of Toronto, Nutritional Sciences , 150 College St, Room 322 , University of Toronto , Toronto, Ontario, Canada , M5S3E2 ; harvey.anderson@utoronto.ca.
11
Mount Saint Vincent Univeristy, Applied Human Nutrition , 166 Bedford HWY , Halifax, Nova Scotia, Canada , B3M 2J6 ; Bohdan.Luhovyy@msvu.ca.

Abstract

In adults, dairy consumption improves short-term blood glucose regulation. It is unknown whether these short-term benefits extend to children of different weight statuses. The objective of this study was to investigate the effect of a dairy and non-dairy snack in both normal weight (NW) and overweight/obese (OW/OB) children on blood glucose regulation and food intake (FI). In a repeated measures crossover design, 11 NW and 7 OW/OB children (age: 9-14y), consumed, in random order, a dairy (Greek yogurt, 198.9g, 171kcal, 0g fat, 17g protein) or non-dairy (mini sandwich type cookies, 37.5g, 175kcal, 7.5g fat, 1.3g protein) snack containing 25g of available carbohydrates. Ad libitum FI was measured 120 min after snack consumption. Blood glucose, insulin, C-peptide, and GLP-1 were measured at 0 min (before the snack), and 30, 60, 90, and 120 min after snack consumption. Insulin secretion was calculated from deconvolution of C-peptide. Hepatic insulin extraction was calculated as C-peptide divided by insulin. FI did not differ between snacks (P=0.55). Mean blood glucose was lower (P<0.001) and insulin higher (P<0.0001) in the 120 min after consuming the dairy snack. C-peptide concentrations (P=0.75) and insulin secretion (P=0.37) were not different between snacks. The increase in insulin was explained by reduced hepatic insulin extraction (P<0.01). Consumption of the dairy snack also increased mean GLP-1 concentrations (P<0.001). In conclusion, consumption of a dairy snack by NW and OW/OB children results in reduced postprandial blood glucose concentrations and elevated circulating insulin compared to a non-dairy snack possibly due to delayed hepatic insulin extraction.

PMID:
30794429
DOI:
10.1139/apnm-2018-0549

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