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Items: 1 to 20 of 124

1.

Effects of gamma-hydroxybutyrate on neurophysiological correlates of performance and conflict monitoring.

Dornbierer DA, Kometer M, Von Rotz R, Studerus E, Gertsch J, Gachet MS, Vollenweider FX, Seifritz E, Bosch OG, Quednow BB.

Eur Neuropsychopharmacol. 2019 Feb 26. pii: S0924-977X(19)30161-0. doi: 10.1016/j.euroneuro.2019.02.004. [Epub ahead of print]

PMID:
30824339
2.

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.

Granchi C, Lapillo M, Glasmacher S, Bononi G, Licari C, Poli G, El Boustani M, Caligiuri I, Rizzolio F, Gertsch J, Macchia M, Minutolo F, Tuccinardi T, Chicca A.

J Med Chem. 2019 Feb 28;62(4):1932-1958. doi: 10.1021/acs.jmedchem.8b01483. Epub 2019 Feb 11.

PMID:
30715876
3.

Optimizing TRPM4 inhibitors in the MHFP6 chemical space.

Delalande C, Awale M, Rubin M, Probst D, Ozhathil LC, Gertsch J, Abriel H, Reymond JL.

Eur J Med Chem. 2019 Mar 15;166:167-177. doi: 10.1016/j.ejmech.2019.01.048. Epub 2019 Jan 24.

PMID:
30708257
4.

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model.

Häfliger P, Graff J, Rubin M, Stooss A, Dettmer MS, Altmann KH, Gertsch J, Charles RP.

J Exp Clin Cancer Res. 2018 Sep 21;37(1):234. doi: 10.1186/s13046-018-0907-z.

5.

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.

Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P.

Mol Psychiatry. 2018 Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print]

6.

The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors.

Reynoso-Moreno I, Chicca A, Flores-Soto ME, Viveros-Paredes JM, Gertsch J.

Front Mol Neurosci. 2018 May 28;11:180. doi: 10.3389/fnmol.2018.00180. eCollection 2018.

7.

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch J, Manera C.

Eur J Med Chem. 2018 Jun 25;154:155-171. doi: 10.1016/j.ejmech.2018.05.019. Epub 2018 May 14.

PMID:
29793210
8.

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J, Lochner M, Peinelt C, Reymond JL, Abriel H.

Br J Pharmacol. 2018 Jun;175(12):2504-2519. doi: 10.1111/bph.14220. Epub 2018 Apr 29.

9.

New cycloartane-type ester triterpenes from Euphorbia pterococca and biological evaluation.

Benabdelaziz I, Gómez-Ruiz S, Benkhaled M, Carralero S, Schenker P, Salm A, Gertsch J, Haba H.

Fitoterapia. 2018 Jun;127:271-278. doi: 10.1016/j.fitote.2018.02.027. Epub 2018 Mar 7.

PMID:
29524564
10.

Endocannabinoid Tone Regulates Human Sebocyte Biology.

Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch J, Di Marzo V, Bíró T, Szabó T.

J Invest Dermatol. 2018 Aug;138(8):1699-1706. doi: 10.1016/j.jid.2018.02.022. Epub 2018 Mar 6.

PMID:
29501385
11.

Analytical and Pharmacological Challenges in Cannabis Research.

Gertsch J.

Planta Med. 2018 Mar;84(4):213. doi: 10.1055/s-0044-101051. Epub 2018 Feb 21. No abstract available.

PMID:
29466823
12.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch J, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T.

J Med Chem. 2018 Feb 8;61(3):1340-1354. doi: 10.1021/acs.jmedchem.7b01845. Epub 2018 Jan 22.

PMID:
29309142
13.

Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.

Bertini S, Chicca A, Gado F, Arena C, Nieri D, Digiacomo M, Saccomanni G, Zhao P, Abood ME, Macchia M, Gertsch J, Manera C.

Bioorg Med Chem. 2017 Dec 15;25(24):6427-6434. doi: 10.1016/j.bmc.2017.10.015. Epub 2017 Oct 16.

14.

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice.

Reynoso-Moreno I, Najar-Guerrero I, Escareño N, Flores-Soto ME, Gertsch J, Viveros-Paredes JM.

J Agric Food Chem. 2017 Nov 1;65(43):9435-9442. doi: 10.1021/acs.jafc.7b02979. Epub 2017 Oct 25.

15.

Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage.

Petrucci V, Chicca A, Glasmacher S, Paloczi J, Cao Z, Pacher P, Gertsch J.

Sci Rep. 2017 Aug 25;7(1):9560. doi: 10.1038/s41598-017-09808-8.

16.

4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.

Patsenker E, Chicca A, Petrucci V, Moghadamrad S, de Gottardi A, Hampe J, Gertsch J, Semmo N, Stickel F.

J Mol Med (Berl). 2017 Oct;95(10):1077-1089. doi: 10.1007/s00109-017-1556-y. Epub 2017 Jul 8.

17.

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.

Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E5006-E5015. doi: 10.1073/pnas.1704065114. Epub 2017 Jun 5.

18.

Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.

ElMokh O, Ruffieux-Daidié D, Roelli MA, Stooss A, Phillips WA, Gertsch J, Dettmer MS, Charles RP.

Oncotarget. 2017 Apr 11;8(15):24604-24620. doi: 10.18632/oncotarget.15599.

19.

Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers.

von Rotz R, Kometer M, Dornbierer D, Gertsch J, Salomé Gachet M, Vollenweider FX, Seifritz E, Bosch OG, Quednow BB.

Psychopharmacology (Berl). 2017 Jul;234(13):1957-1968. doi: 10.1007/s00213-017-4603-z. Epub 2017 Apr 20.

20.

Biological evaluation of pyridone alkaloids on the endocannabinoid system.

Chicca A, Berg R, Jessen HJ, Marck N, Schmid F, Burch P, Gertsch J, Gademann K.

Bioorg Med Chem. 2017 Nov 15;25(22):6102-6114. doi: 10.1016/j.bmc.2017.02.031. Epub 2017 Feb 17.

PMID:
28284861

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