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Genomic mapping and survival prediction in glioblastoma: molecular subclassification strengthened by hemodynamic imaging biomarkers.
Jain R, Poisson L, Narang J, Gutman D, Scarpace L, Hwang SN, Holder C, Wintermark M, Colen RR, Kirby J, Freymann J, Brat DJ, Jaffe C, Mikkelsen T. Jain R, et al. Radiology. 2013 Apr;267(1):212-20. doi: 10.1148/radiol.12120846. Epub 2012 Dec 13. Radiology. 2013. PMID: 23238158 Free PMC article.
PURPOSE: To correlate tumor blood volume, measured by using dynamic susceptibility contrast material-enhanced T2*-weighted magnetic resonance (MR) perfusion studies, with patient survival and determine its association with molecular subclasses of glioblastoma (GBM). …
PURPOSE: To correlate tumor blood volume, measured by using dynamic susceptibility contrast material-enhanced T2*-weighted magnetic resonanc …
ADD3 Deletion in Glioblastoma Predicts Disease Status and Survival.
Kiang KM, Sun S, Leung GK. Kiang KM, et al. Front Oncol. 2021 Dec 14;11:717793. doi: 10.3389/fonc.2021.717793. eCollection 2021. Front Oncol. 2021. PMID: 34970477 Free PMC article.
In this study, we unveil how the assessment of ADD3 deletion provides clinical significance in glioblastoma (GBM). By deletion mapping, we assessed the frequency of LOH in forty-three glioma specimens using five microsatellite markers spanning chromosome 10q23-10qte …
In this study, we unveil how the assessment of ADD3 deletion provides clinical significance in glioblastoma (GBM). By deletion map …
Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma.
Walentynowicz KA, Engelhardt D, Cristea S, Yadav S, Onubogu U, Salatino R, Maerken M, Vincentelli C, Jhaveri A, Geisberg J, McDonald TO, Michor F, Janiszewska M. Walentynowicz KA, et al. Cell Rep. 2023 Mar 28;42(3):112235. doi: 10.1016/j.celrep.2023.112235. Epub 2023 Mar 14. Cell Rep. 2023. PMID: 36920905 Free PMC article.
Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of 15 months. ...Single-cell FISH analysis of a total of 35,843 single nuclei reveals that tumors in which amplifications of EGFR and CDK4 more frequently co-occur in the same cell exhibit …
Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of 15 months. ...Single-cell FISH analysis of a …
A Serum Proteomic Signature Predicting Survival in Patients with Glioblastoma.
Sproull M, Mathen P, Miller CA, Mackey M, Cooley T, Smart D, Shankavaram U, Camphausen K. Sproull M, et al. J Biochem Anal Stud. 2020 Mar;4(1):10.16966/2576-5833.117. doi: 10.16966/2576-5833.117. Epub 2019 Oct 26. J Biochem Anal Stud. 2020. PMID: 33884377 Free PMC article.
PURPOSE: Glioblastoma (GBM) is the most common form of brain tumor and has a uniformly poor prognosis. ...Analysis of potentially relevant gene targets using The Cancer Genome Atlas database was done using the Glioblastoma Bio Discovery Portal (GBM-BioDP). .. …
PURPOSE: Glioblastoma (GBM) is the most common form of brain tumor and has a uniformly poor prognosis. ...Analysis of potentially rel …
Radiogenomic mapping of edema/cellular invasion MRI-phenotypes in glioblastoma multiforme.
Zinn PO, Mahajan B, Sathyan P, Singh SK, Majumder S, Jolesz FA, Colen RR. Zinn PO, et al. PLoS One. 2011;6(10):e25451. doi: 10.1371/journal.pone.0025451. Epub 2011 Oct 5. PLoS One. 2011. PMID: 21998659 Free PMC article.
The top downregulated microRNA in both sets was miR-219, which is predicted to bind to POSTN. Kaplan Meier analysis demonstrated that above median expression of POSTN resulted in significantly decreased survival and shorter time to disease progression (P<0.001). …
The top downregulated microRNA in both sets was miR-219, which is predicted to bind to POSTN. Kaplan Meier analysis demonstrated that …
LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients.
Mock A, Geisenberger C, Orlik C, Warta R, Schwager C, Jungk C, Dutruel C, Geiselhart L, Weichenhan D, Zucknick M, Nied AK, Friauf S, Exner J, Capper D, Hartmann C, Lahrmann B, Grabe N, Debus J, von Deimling A, Popanda O, Plass C, Unterberg A, Abdollahi A, Schmezer P, Herold-Mende C. Mock A, et al. Int J Cancer. 2016 Jul 15;139(2):424-32. doi: 10.1002/ijc.30069. Epub 2016 Mar 18. Int J Cancer. 2016. PMID: 26934681 Free article.
MGMT promoter methylation status is currently the only established molecular prognosticator in IDH wild-type glioblastoma multiforme (GBM). Therefore, we aimed to discover novel therapy-associated epigenetic biomarkers. ...These DMRs were further assessed for their prognos …
MGMT promoter methylation status is currently the only established molecular prognosticator in IDH wild-type glioblastoma multiforme …
Role of alternative splicing signatures in the prognosis of glioblastoma.
Xie ZC, Wu HY, Dang YW, Chen G. Xie ZC, et al. Cancer Med. 2019 Dec;8(18):7623-7636. doi: 10.1002/cam4.2666. Epub 2019 Nov 1. Cancer Med. 2019. PMID: 31674730 Free PMC article.
However, comprehensive investigations on the entirety of AS and their clinical value in glioblastoma (GBM) are lacking. METHODS: The AS profiles and clinical survival data related to GBM were obtained from The Cancer Genome Atlas database. ...The Kaplan-Meier …
However, comprehensive investigations on the entirety of AS and their clinical value in glioblastoma (GBM) are lacking. METHODS: The …
The ALDH Family Contributes to Immunocyte Infiltration, Proliferation and Epithelial-Mesenchymal Transformation in Glioma.
Wang Z, Mo Y, Tan Y, Wen Z, Dai Z, Zhang H, Zhang X, Feng S, Liang X, Song T, Cheng Q. Wang Z, et al. Front Immunol. 2022 Jan 7;12:756606. doi: 10.3389/fimmu.2021.756606. eCollection 2021. Front Immunol. 2022. PMID: 35116021 Free PMC article.
Bulk RNA-seq analysis and single-cell RNA-Seq analysis were performed to explore the role of the aldehyde dehydrogenases family in gliomas. Training cohort contained The Cancer Genome Atlas data, while data from Chinese Glioma Genome Atlas and Gene Expression Omnibu …
Bulk RNA-seq analysis and single-cell RNA-Seq analysis were performed to explore the role of the aldehyde dehydrogenases family in gliomas. …
Discovering and interpreting transcriptomic drivers of imaging traits using neural networks.
Smedley NF, El-Saden S, Hsu W. Smedley NF, et al. Bioinformatics. 2020 Jun 1;36(11):3537-3548. doi: 10.1093/bioinformatics/btaa126. Bioinformatics. 2020. PMID: 32101278 Free PMC article.
In glioblastoma patients, our models outperformed comparable classifiers (>0.10 AUC) and our interpretation methods were validated using a similar model to identify known relationships between genes and molecular subtypes. We found that tumor imaging traits had specific …
In glioblastoma patients, our models outperformed comparable classifiers (>0.10 AUC) and our interpretation methods were validated …
Imaging genomic mapping of an invasive MRI phenotype predicts patient outcome and metabolic dysfunction: a TCGA glioma phenotype research group project.
Colen RR, Vangel M, Wang J, Gutman DA, Hwang SN, Wintermark M, Jain R, Jilwan-Nicolas M, Chen JY, Raghavan P, Holder CA, Rubin D, Huang E, Kirby J, Freymann J, Jaffe CC, Flanders A; TCGA Glioma Phenotype Research Group; Zinn PO. Colen RR, et al. BMC Med Genomics. 2014 Jun 2;7:30. doi: 10.1186/1755-8794-7-30. BMC Med Genomics. 2014. PMID: 24889866 Free PMC article.
BACKGROUND: Invasion of tumor cells into adjacent brain parenchyma is a major cause of treatment failure in glioblastoma. Furthermore, invasive tumors are shown to have a different genomic composition and metabolic abnormalities that allow for a more aggressive GBM …
BACKGROUND: Invasion of tumor cells into adjacent brain parenchyma is a major cause of treatment failure in glioblastoma. Furthermore …
21 results