Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Nat Commun. 2018 Jul 27;9(1):2941. doi: 10.1038/s41467-018-04951-w.

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

Author information

1
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
2
The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
3
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
4
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
5
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia. j.zeng@uq.edu.au.
6
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia. jian.yang@uq.edu.au.
7
The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. jian.yang@uq.edu.au.
8
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia. jian.yang@uq.edu.au.

Abstract

Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of which (39 common and 3 rare variants) are independent of the known variants. Integration of the gene expression data from blood (n = 14,115 and 2765) with the GWAS results identifies 33 putative functional genes for T2D, 3 of which were targeted by approved drugs. A further integration of DNA methylation (n = 1980) and epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) with plausible regulatory mechanisms, whereby a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression. Our study uncovers additional loci, proposes putative genetic regulatory mechanisms for T2D, and provides evidence of purifying selection for T2D-associated variants.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center