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Psychiatr Genet. 2017 Oct;27(5):178-186. doi: 10.1097/YPG.0000000000000178.

Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes.

Author information

1
aThe Menninger Clinic bThe Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine cMichael E. DeBakey Veterans Affairs Medical Center; Houston, Texas dStatistical and Genetic Consulting LLC, Daren, Connecticut, USA.

Abstract

OBJECTIVE:

This study investigated variants of tryptophan hydroxylase (TPH)1, TPH2, and SLC6A4 in the moderation of the subjective effects of cocaine.

METHODS:

Non-treatment-seeking cocaine-dependent individuals (N=66) were intravenously administered saline and cocaine (40 mg) in a randomized order. Participants self-reported subjective effects of cocaine using a visual analog scale starting before administration of saline or cocaine (-15 min) to up to 20 min after infusion. Self-report ratings on the visual analog scale ranged from 0 (no effect) to 100 (greatest effect). Participants were genotyped for the TPH1 rs1799913, TPH2 rs4290270, and SLC6A4 5-HTTLPR variants. Repeated-measures analysis of covariance was used to examine changes in subjective effect scores over time while controlling for population structure.

RESULTS:

Participants carrying the TPH1 rs1799913 A allele reported greater subjective response to cocaine for 'stimulated' and 'access' relative to the CC genotype group. Those carrying the TPH2 rs4290270 A allele reported higher 'good effect' and lower 'depressed' effect relative to the TT genotype group. Those carrying the SLC6A4 5-HTTLPR S' allele reported greater 'desire' and 'access' compared with the L'L' genotype group.

CONCLUSION:

These findings indicate that TPH1, TPH2, and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.

PMID:
28590957
PMCID:
PMC5572746
DOI:
10.1097/YPG.0000000000000178
[Indexed for MEDLINE]
Free PMC Article

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