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PLoS Curr. 2010 Sep 5;2:RRN1165.

Genetic content of Influenza H3N2 vaccine seeds.

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Université; Lyon 1; CNR Virus Influenza région sud - Hospices Civils de Lyon; NIC Lyon & UCBL-CNRS FRE 3011, Lyon, and VirPath FRE3011, Université Lyon1, France.


Influenza vaccine seeds produced in chicken eggs are selected through HA and NA surface glycoproteins antigenicity, as well as through high replicative ability. Here we characterize the genetic content of recently used thirteen H3N2 influenza vaccine seeds. Interestingly, sequence analysis of the vaccine seeds shows reassortment events leading to PR8:H3N2 segment constellations, ranging from the 6:2 to 2:6 constellations. This study shows that the H3N2 PB1 is the most frequent internal segment incorporated in the tested vaccines seeds.


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