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Neuron. 2015 Dec 2;88(5):941-956. doi: 10.1016/j.neuron.2015.10.046. Epub 2015 Nov 20.

Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2.

Author information

1
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794, USA.
2
Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA.
3
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA; Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
4
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA.
5
Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
6
Department of Psychology, Stony Brook University, Stony Brook, NY 11794, USA.
7
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: adan.aguirre@stonybrook.edu.

Abstract

NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active pool of cells in the central nervous system (CNS). In addition to serving as progenitors of myelinating oligodendrocytes, NG2 glia might also fulfill physiological roles in CNS homeostasis, although the mechanistic nature of such roles remains unclear. Here, we report that ablation of NG2 glia in the prefrontal cortex (PFC) of the adult brain causes deficits in excitatory glutamatergic neurotransmission and astrocytic extracellular glutamate uptake and induces depressive-like behaviors in mice. We show in parallel that chronic social stress causes NG2 glia density to decrease in areas critical to Major Depressive Disorder (MDD) pathophysiology at the time of symptom emergence in stress-susceptible mice. Finally, we demonstrate that loss of NG2 glial secretion of fibroblast growth factor 2 (FGF2) suffices to induce the same behavioral deficits. Our findings outline a pathway and role for NG2 glia in CNS homeostasis and mood disorders.

PMID:
26606998
PMCID:
PMC5354631
DOI:
10.1016/j.neuron.2015.10.046
[Indexed for MEDLINE]
Free PMC Article

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