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Pharmacopsychiatry. 2007 Dec;40 Suppl 1:S73-7. doi: 10.1055/s-2007-992130.

Gating deficits in model networks: a path to schizophrenia?

Author information

1
Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York 10032-2695, USA. timvogels@columbia.edu

Abstract

Gating deficits and hallucinatory sensations are prominent symptoms of schizophrenia. Comparing these abnormalities with the failure modes of network models is an interesting way to explore how they arise. We present a network model that can both propagate and gate signals. The model exhibits effects reminiscent of clinically observed pathologies when the balance between excitation and inhibition that it requires is not properly maintained.

PMID:
18080946
DOI:
10.1055/s-2007-992130
[Indexed for MEDLINE]

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