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Carbohydr Polym. 2014 Mar 15;103:520-7. doi: 10.1016/j.carbpol.2013.12.080. Epub 2014 Jan 6.

Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway.

Author information

1
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
2
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address: spnie@ncu.edu.cn.
3
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

Abstract

A newly identified polysaccharide (PSG-1) has been purified from Ganoderma atrum. The study was to investigate the protective effect of PSG-1 on diabetes-induced endothelial dysfunction in rat aorta. Rats were fed a high fat diet for 8 weeks and then injected with a low dose of streptozotocin to induce type 2 diabetes. The diabetic rats were orally treated with PSG-1 for 4 weeks. It was found that administration of PSG-1 significantly reduced levels of fasting blood glucose, improved endothelium-dependent aortic relaxation, increased levels of phosphoinositide 3-kinase (PI3K), phospho-Akt (p-Akt), endothelial nitric oxide synthase (eNOS) and nitric oxide in the aorta from diabetic rats, compared to un-treated diabetics. These results suggested that the protective effects of PSG-1 against endothelial dysfunction may be related to activation of the PI3K/Akt/eNOS pathway.

KEYWORDS:

Aorta; Ganoderma atrum polysaccharide; Vascular endothelium; Vasorelaxation

PMID:
24528762
DOI:
10.1016/j.carbpol.2013.12.080
[Indexed for MEDLINE]

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