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Nephrol Dial Transplant. 2015 Nov;30(11):1814-24. doi: 10.1093/ndt/gfv048. Epub 2015 Apr 9.

Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease.

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Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany.
Department of Internal Medicine 4, Saarland University Hospital, Homburg/Saar, Germany.


Post-translational modifications (PTMs) of proteins and peptides have recently gained much attention, as they are involved in the pathogenesis of cardiovascular disease and eventually also play a role in the progression of chronic kidney disease (CKD). In this review, we provide an overview of post-translational protein modifications such as carbamylation, glycation and oxidation, starting with their definitions, mechanisms and clinical relevance in the setting of CKD and cardiovascular disease. The methods currently used for the identification and, in particular, quantification of PTMs are described and potential treatment options in the context of PTMs are reviewed. We foresee that advancements in mass spectrometry-based methods leading to the identification of novel disease markers and/or pathophysiologically relevant factors will certainly boost the clinical utility in sample analyses.


carbamylation; cardiovascular disease; chronic kidney disease; oxidation; post-translational modification

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