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The Evolution of Single Cell-derived Colorectal Cancer Cell Lines is Dominated by the Continued Selection of Tumor Specific Genomic Imbalances, Despite Random Chromosomal Instability.

Wangsa D, Braun R, Schiefer M, Gertz EM, Bronder D, Quintanilla I, Padilla-Nash HM, Torres I, Hunn C, Warner L, Buishand FO, Hu Y, Hirsch D, Gaiser T, Camps J, Schwartz R, Schäffer AA, Heselmeyer-Haddad K, Ried T.

Carcinogenesis. 2018 May 23. doi: 10.1093/carcin/bgy068. [Epub ahead of print]


Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, Das S, Eijk PP, Murphy V, Barat A, Bacon O, Prehn JHM, Betge J, Gaiser T, Fender B, Meijer GA, McNamara DA, Klinger R, Koopman M, Ebert MPA, Kay EW, Hennessey BT, Verheul HMW, Gallagher WM, O'Connor DP, Punt CJA, Loupakis F, Lambrechts D, Byrne AT, van Grieken NCT, Ylstra B.

J Clin Oncol. 2018 May 24:JCO2017771782. doi: 10.1200/JCO.2017.77.1782. [Epub ahead of print]


Cecal Resection with Bipolar Sealing Devices in a Rat Model.

Tagkalos E, Heimann A, Gaiser T, Hirsch D, Gockel I, Lang H, Jansen-Winkeln B.

J Invest Surg. 2018 May 18:1-8. doi: 10.1080/08941939.2018.1469698. [Epub ahead of print]


MYC gene amplification is a rare event in atypical fibroxanthoma and pleomorphic dermal sarcoma.

Gaiser T, Hirsch D, Orouji A, Bach M, Kind P, Helbig D, Quaas A, Utikal J, Marx A, Gaiser MR.

Oncotarget. 2018 Apr 20;9(30):21182-21189. doi: 10.18632/oncotarget.24997. eCollection 2018 Apr 20.


Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells.

Gaiser MR, Weis CA, Gaiser T, Jiang H, Buder-Bakhaya K, Herpel E, Warth A, Xiao Y, Miao L, Brownell I.

Oncoimmunology. 2018 Feb 8;7(5):e1426517. doi: 10.1080/2162402X.2018.1426517. eCollection 2018.


PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice.

Gutting T, Weber CA, Weidner P, Herweck F, Henn S, Friedrich T, Yin S, Kzhyshkowska J, Gaiser T, Janssen KP, Reindl W, Ebert MPA, Burgermeister E.

Oncoimmunology. 2018 Feb 1;7(5):e1423168. doi: 10.1080/2162402X.2017.1423168. eCollection 2018.


Pringle maneuver increases the risk of anastomotic leakage after colonic resection in rats.

Jansen-Winkeln B, Tagkalos E, Heimann A, Gaiser T, Hirsch D, Gockel I, Mittler J, Lang H, Heinrich S.

HPB (Oxford). 2018 May;20(5):392-397. doi: 10.1016/j.hpb.2017.10.010. Epub 2018 Jan 4.


Contribution of crop model structure, parameters and climate projections to uncertainty in climate change impact assessments.

Tao F, Rötter RP, Palosuo T, Gregorio Hernández Díaz-Ambrona C, Mínguez MI, Semenov MA, Kersebaum KC, Nendel C, Specka X, Hoffmann H, Ewert F, Dambreville A, Martre P, Rodríguez L, Ruiz-Ramos M, Gaiser T, Höhn JG, Salo T, Ferrise R, Bindi M, Cammarano D, Schulman AH.

Glob Chang Biol. 2018 Mar;24(3):1291-1307. doi: 10.1111/gcb.14019. Epub 2018 Jan 4.


Epigenetic silencing of tumor suppressor candidate 3 confers adverse prognosis in early colorectal cancer.

Burgermeister E, Höde P, Betge J, Gutting T, Merkel A, Wu W, Tänzer M, Mossner M, Nowak D, Magdeburg J, Rückert F, Sticht C, Breitkopf-Heinlein K, Schulte N, Härtel N, Belle S, Post S, Gaiser T, Heppner BI, Behrens HM, Röcken C, Ebert MPA.

Oncotarget. 2017 Sep 15;8(49):84714-84728. doi: 10.18632/oncotarget.20950. eCollection 2017 Oct 17.


Panitumumab in Combination With Preoperative Radiation Therapy in Patients With Locally Advanced RAS Wild-type Rectal Cancer: Results of the Multicenter Explorative Single-Arm Phase 2 Study NEORIT.

Merx K, Martens UM, Kripp M, Hoehler T, Geissler M, Gaiser T, Mai S, Kienle P, Belle S, Plöger C, Hieber U, Wenz F, Post S, Hofheinz RD.

Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):867-875. doi: 10.1016/j.ijrobp.2017.06.2460. Epub 2017 Jun 28.


[Good remission under HER2 blockade in an advanced carcinoma of the oesophagogastric junction with only focal HER2 overexpression].

Gaiser T, Hirsch D, Hofheinz RD.

Z Gastroenterol. 2017 Sep;55(9):866-871. doi: 10.1055/s-0043-116493. Epub 2017 Aug 8. German.


Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.

Meißner T, Mark A, Williams C, Berdel WE, Wiebe S, Kerkhoff A, Wardelmann E, Gaiser T, Müller-Tidow C, Rosenstiel P, Arnold N, Leyland-Jones B, Franke A, Stanulla M, Forster M.

Cold Spring Harb Mol Case Stud. 2017 Jul 5;3(4). pii: a001677. doi: 10.1101/mcs.a001677. Print 2017 Jul.


P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1.

Laudato S, Patil N, Abba ML, Leupold JH, Benner A, Gaiser T, Marx A, Allgayer H.

Int J Cancer. 2017 Nov 1;141(9):1879-1890. doi: 10.1002/ijc.30854. Epub 2017 Jul 24.


Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn's Disease.

Galata C, Hirsch D, Reindl W, Post S, Kienle P, Boutros M, Gaiser T, Horisberger K.

J Clin Gastroenterol. 2017 Jun 26. doi: 10.1097/MCG.0000000000000817. [Epub ahead of print]


Langerhans and Merkel: a nervous epidermal dispute.

Gaiser MR, Gaiser T.

Virchows Arch. 2018 Feb;472(2):281-284. doi: 10.1007/s00428-017-2168-1. Epub 2017 Jun 16. No abstract available.


Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach.

Moran B, Das S, Smeets D, Peutman G, Klinger R, Fender B, Connor K, Ebert M, Gaiser T, Prehn JH, Bacon O, Kay E, Hennessy B, Murphy V, Ylstra B, Lambrechts D, Byrne AT, Gallagher WM, O'Connor DP.

Oncotarget. 2017 Jul 18;8(29):48126-48137. doi: 10.18632/oncotarget.18296.


Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.

Zuurbier L, Rahman A, Cordes M, Scheick J, Wong TJ, Rustenburg F, Joseph JC, Dynoodt P, Casey R, Drillenburg P, Gerhards M, Barat A, Klinger R, Fender B, O'Connor DP, Betge J, Ebert MP, Gaiser T, Prehn JHM, Griffioen AW, van Grieken NCT, Ylstra B, Byrne AT, van der Flier LG, Gallagher WM, Postel R.

Oncotarget. 2017 Jun 27;8(26):42949-42961. doi: 10.18632/oncotarget.17306.


HER2 testing in gastric cancer: results of a German expert meeting.

Lordick F, Al-Batran SE, Dietel M, Gaiser T, Hofheinz RD, Kirchner T, Kreipe HH, Lorenzen S, Möhler M, Quaas A, Röcken C, Rüschoff J, Tannapfel A, Thuss-Patience P, Baretton G.

J Cancer Res Clin Oncol. 2017 May;143(5):835-841. doi: 10.1007/s00432-017-2374-x. Epub 2017 Mar 11. Review.


Identification of a characteristic vascular belt zone in human colorectal cancer.

Kather JN, Zöllner FG, Schad LR, Melchers SM, Sinn HP, Marx A, Gaiser T, Weis CA.

PLoS One. 2017 Mar 2;12(3):e0171378. doi: 10.1371/journal.pone.0171378. eCollection 2017. Erratum in: PLoS One. 2017 May 8;12 (5):e0177586.


Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice.

Feng T, Dzieran J, Yuan X, Dropmann A, Maass T, Teufel A, Marhenke S, Gaiser T, Rückert F, Kleiter I, Kanzler S, Ebert MP, Vogel A, Ten Dijke P, Dooley S, Meindl-Beinker NM.

Oncogenesis. 2017 Jan 30;6(1):e294. doi: 10.1038/oncsis.2016.85.

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