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The Gem interacting protein (GMIP) gene is associated with major depressive disorder.
Tadokoro K, Hashimoto R, Tatsumi M, Kosuga A, Kamijima K, Kunugi H. Tadokoro K, et al. Neurogenetics. 2005 Sep;6(3):127-33. doi: 10.1007/s10048-005-0003-3. Epub 2005 Sep 28. Neurogenetics. 2005. PMID: 16086184
Structural neuronal impairment has been considered to be implicated in MDD, as it leads to brain morphological alterations such as hippocampal atrophy. The Gem interacting protein, GMIP, is a novel Rho GTPase-activating protein known to play imp …
Structural neuronal impairment has been considered to be implicated in MDD, as it leads to brain morphological alterations such as hippocamp …
A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases.
Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J. Aresta S, et al. Biochem J. 2002 Oct 1;367(Pt 1):57-65. doi: 10.1042/BJ20020829. Biochem J. 2002. PMID: 12093360 Free PMC article.
The RhoGAP domain of Gmip stimulates in vitro the GTPase activity of RhoA, but is inactive towards other Rho family proteins such as Rac1 and Cdc42; it is also specific for RhoA in vivo. ...These findings suggest that the signalling pathways controlled by two pro …
The RhoGAP domain of Gmip stimulates in vitro the GTPase activity of RhoA, but is inactive towards other Rho family proteins s …
Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.
Johnson JL, Monfregola J, Napolitano G, Kiosses WB, Catz SD. Johnson JL, et al. Mol Biol Cell. 2012 May;23(10):1902-16. doi: 10.1091/mbc.E11-12-1001. Epub 2012 Mar 21. Mol Biol Cell. 2012. PMID: 22438581 Free PMC article.
Using a proteomic approach, we identified the RhoA-GTPase-activating protein Gem-interacting protein (GMIP) as a factor that associates with the Rab27a effector JFC1 and modulates vesicular transport and exocytosis. GMIP down-regulation i …
Using a proteomic approach, we identified the RhoA-GTPase-activating protein Gem-interacting protein (GMIP …
Identification of herpesvirus proteins that contribute to G1/S arrest.
Paladino P, Marcon E, Greenblatt J, Frappier L. Paladino P, et al. J Virol. 2014 Apr;88(8):4480-92. doi: 10.1128/JVI.00059-14. Epub 2014 Feb 5. J Virol. 2014. PMID: 24501404 Free PMC article.
Two EBV replication proteins (BORF2 and BMRF1) were found to induce p53 but not p21, while a previously uncharacterized tegument protein (BGLF2) was found to induce p21 protein levels in a p53-independent manner. Proteomic analyses of BGLF2-interacting pro …
Two EBV replication proteins (BORF2 and BMRF1) were found to induce p53 but not p21, while a previously uncharacterized tegument p …
Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA.
Ota H, Hikita T, Sawada M, Nishioka T, Matsumoto M, Komura M, Ohno A, Kamiya Y, Miyamoto T, Asai N, Enomoto A, Takahashi M, Kaibuchi K, Sobue K, Sawamoto K. Ota H, et al. Nat Commun. 2014 Jul 30;5:4532. doi: 10.1038/ncomms5532. Nat Commun. 2014. PMID: 25074242 Free article.
Rho signalling is known to affect the morphology and movement of various cell types, including neurons. Here we identify Gem-interacting protein (Gmip), a RhoA-specific GTPase-activating protein, as a key factor in saltatory neuronal migration. …
Rho signalling is known to affect the morphology and movement of various cell types, including neurons. Here we identify Gem-inter …
The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor.
Amaar YG, Reeves ME. Amaar YG, et al. Oncotarget. 2020 Nov 10;11(45):4082-4092. doi: 10.18632/oncotarget.27795. eCollection 2020 Nov 10. Oncotarget. 2020. PMID: 33227088 Free PMC article.
Over-expression of RASSF1C and knocking down RASSF1C and PIWIL1 modulated DNA methylation of genomic regions; and statistically significant candidate genes residing DMR regions in lung cancer cells were identified, including oncogenes and tumor suppressors. One of the hypermethyl …
Over-expression of RASSF1C and knocking down RASSF1C and PIWIL1 modulated DNA methylation of genomic regions; and statistically significant …