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Page 1
Practical and concise synthesis of nucleoside analogs.
Davison EK, Petrone DA, Meanwell M, Nodwell MB, Silverman SM, Campeau LC, Britton R. Davison EK, et al. Nat Protoc. 2022 Sep;17(9):2008-2024. doi: 10.1038/s41596-022-00705-7. Epub 2022 Jul 4. Nat Protoc. 2022. PMID: 35788720 Review.
The novel methodology described in this protocol addresses several longstanding challenges in nucleoside analog synthesis by enabling flexible and selective access to nucleoside analogs possessing variable nucleobase substitution, D- or L-configuration, selective protection of …
The novel methodology described in this protocol addresses several longstanding challenges in nucleoside analog synthesis by enabling flexib …
Zipper-like Watson-Crick base-pairs.
Chou SH, Chin KH. Chou SH, et al. J Mol Biol. 2001 Sep 28;312(4):753-68. doi: 10.1006/jmbi.2001.4962. J Mol Biol. 2001. PMID: 11575930
A series of DNA heptadecamers containing the DNA analogues of RNA E-like 5'-d(GXA)/(AYG)-5' motifs (X/Y is complementary T/A, A/T, C/G, or G/C pair) were studied using nuclear magnetic resonance (NMR) methodology and distance geometry (DG)/molecular dynamics (MD) ap …
A series of DNA heptadecamers containing the DNA analogues of RNA E-like 5'-d(GXA)/(AYG)-5' motifs (X/Y is complementary T/A, A/T, C/G …
Breed-specific differences in the immune response to lipopolysaccharide in ewes.
Hadfield JM, Bowdridge EC, Holásková I, Elsasser TH, Dailey RA. Hadfield JM, et al. J Anim Sci. 2018 Sep 29;96(10):4220-4228. doi: 10.1093/jas/sky288. J Anim Sci. 2018. PMID: 30107562 Free PMC article.

After LPS treatment, gene expressions increased for CXCL8 (P = 0.0003), TLR4 (P = 0.004), SOD2 (P < 0.0001), and C3 (P = 0.003), while PPARG (P = 0.006) and MRC1 (P = 0.003) decreased. Overall, Dorset ewes had greater expression of TLR4 (P = 0.003), IL-10 (P = 0.045), P

…

After LPS treatment, gene expressions increased for CXCL8 (P = 0.0003), TLR4 (P = 0.004), SOD2 (P < 0.0001), and C3 (P = 0.003), w

…
Unveiling the Nature of Pt Single-Atom Catalyst during Electrocatalytic Hydrogen Evolution and Oxygen Reduction Reactions.
Li J, Banis MN, Ren Z, Adair KR, Doyle-Davis K, Meira DM, Finfrock YZ, Zhang L, Kong F, Sham TK, Li R, Luo J, Sun X. Li J, et al. Small. 2021 Mar;17(11):e2007245. doi: 10.1002/smll.202007245. Epub 2021 Feb 19. Small. 2021. PMID: 33605070 Review.
In this work, high loading Pt single atoms on graphitic carbon nitride (g-C(3) N(4) )-derived N-doped carbon nanosheets (Pt(1) /NCNS) is achieved through atomic layer deposition. ...The operando results indicate that the total unoccupied density of states of Pt 5d o …
In this work, high loading Pt single atoms on graphitic carbon nitride (g-C(3) N(4) )-derived N-doped carbon nanosheets (Pt(1) /NCNS) …
Dual fluorescence properties and enhanced thermal stability of SrSi(2)O(2)N(2):Eu(2+) phosphors by coupling with g-C(3)N(4).
Wang J, Song H, Dong P, Zhao Z, Zhang Y. Wang J, et al. RSC Adv. 2023 Feb 23;13(10):6442-6452. doi: 10.1039/d2ra07562h. eCollection 2023 Feb 21. RSC Adv. 2023. PMID: 36845593 Free PMC article.
Notably, the dual emissions at 460 nm (blue) and 520 nm (green) were observed for the SrSi(2)O(2)N(2):Eu(2+)/g-C(3)N(4) composite under near-ultraviolet (NUV) excitation, attributed to the g-C(3)N(4) and 5d-4f transition of Eu(2+) ions, respectively. The coup …
Notably, the dual emissions at 460 nm (blue) and 520 nm (green) were observed for the SrSi(2)O(2)N(2):Eu(2+)/g-C(3)N(4) composite und …
Molecular Modeling Studies of Novel Fluoroquinolone Molecules.
Allaka TR, Katari NK, Veeramreddy V, Anireddy JS. Allaka TR, et al. Curr Drug Discov Technol. 2018;15(2):109-122. doi: 10.2174/1570163814666170829142044. Curr Drug Discov Technol. 2018. PMID: 28875852
Melting points were uncorrected and determined in open capillary tubes in a melting point apparatus. TLC was performed on silica gel-G and spotting was done using iodine/ KMnO4 staining or UV-light. ...From the docking study, we have explored the probable binding mode and …
Melting points were uncorrected and determined in open capillary tubes in a melting point apparatus. TLC was performed on silica gel-G …
Telomerase Inhibition and Human Telomeric G-Quadruplex DNA Stabilization by a beta-Carboline-Benzimidazole Derivative at Low Concentrations.
Yadav K, Meka PNR, Sadhu S, Guggilapu SD, Kovvuri J, Kamal A, Srinivas R, Devayani P, Babu BN, Nagesh N. Yadav K, et al. Biochemistry. 2017 Aug 22;56(33):4392-4404. doi: 10.1021/acs.biochem.7b00008. Epub 2017 Aug 10. Biochemistry. 2017. PMID: 28737386
In this study, G4 DNA stabilization, inhibition of telomerase, and anticancer activity of synthetic beta-carboline-benzimidazole derivatives (5a, 5d, 5h, and 5r) were studied. Among them, derivatives containing a 4-methoxyphenyl ring at C(1) and a 6-methoxy-substituted ben …
In this study, G4 DNA stabilization, inhibition of telomerase, and anticancer activity of synthetic beta-carboline-benzimidazole derivatives …
Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
Kowal EA, Lad RR, Pallan PS, Dhummakupt E, Wawrzak Z, Egli M, Sturla SJ, Stone MP. Kowal EA, et al. Nucleic Acids Res. 2013 Aug;41(15):7566-76. doi: 10.1093/nar/gkt488. Epub 2013 Jun 8. Nucleic Acids Res. 2013. PMID: 23748954 Free PMC article.
The structure of the modified Dickerson-Drew dodecamer (DDD) in which guanine at position G(4) has been replaced by O(6)-Bn-dG and cytosine C(9) has been replaced with dPer to form the modified O(6)-Bn-dG:dPer (DDD-XY) duplex [5'-d(C(1)G(2)C(3)X(4)A(5)A(6)T(7)T(8)Y( …
The structure of the modified Dickerson-Drew dodecamer (DDD) in which guanine at position G(4) has been replaced by O(6)-Bn-dG and cy …
Base-Displaced Intercalated Conformation of the 2-Amino-3-methylimidazo[4,5-f]quinoline N(2)-dG DNA Adduct Positioned at the Nonreiterated G(1) in the NarI Restriction Site.
Stavros KM, Hawkins EK, Rizzo CJ, Stone MP. Stavros KM, et al. Chem Res Toxicol. 2015 Jul 20;28(7):1455-68. doi: 10.1021/acs.chemrestox.5b00140. Epub 2015 Jun 17. Chem Res Toxicol. 2015. PMID: 26083477 Free PMC article.
The conformation of an N(2)-dG adduct arising from the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a potent food mutagen, was determined in 5'-d(C(1)T(2)C(3)X(4)G(5)C(6)G(7)C(8)C(9)A(10)T(11)C(12))-3':5'-d(G(13)A(14)T(15)G(16)G …
The conformation of an N(2)-dG adduct arising from the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a potent food mutage …
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.
Spadoni G, Balsamini C, Bedini A, Diamantini G, Di Giacomo B, Tontini A, Tarzia G, Mor M, Plazzi PV, Rivara S, Nonno R, Pannacci M, Lucini V, Fraschini F, Stankov BM. Spadoni G, et al. J Med Chem. 1998 Sep 10;41(19):3624-34. doi: 10.1021/jm970721h. J Med Chem. 1998. PMID: 9733487
On the basis of a novel in vitro functional assay (specific binding of [35S]GTPgammaS), which can discriminate agonist from partial agonist, antagonist, and inverse agonist ligands, 5a,g, h,j and 13 were shown to be partial agonists, 5d,e and 8-11 competitive antago …
On the basis of a novel in vitro functional assay (specific binding of [35S]GTPgammaS), which can discriminate agonist from partial agonist, …
38 results