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Nanoscale. 2015 Nov 21;7(43):18036-43. doi: 10.1039/c5nr04173b.

Functionalized nanomaterials: are they effective to perform gene delivery to difficult-to-transfect cells with no cytotoxicity?

Author information

1
Cell Signaling and Nanobiotechnology Laboratory, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil. rrresende@hotmail.com contato@institutonanocell.org.br and Nanocell Institute, Divinópolis, Brazil.
2
Cell Biology Laboratory, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
3
Chemistry of Nanostructures Laboratory, Nuclear Technology Development Center, Federal University of Minas Gerais, Belo Horizonte, Brazil.
4
Cell Electrophysiology Laboratory, Department of Physiology and Pharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
5
Excitable Membranes Laboratory, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
6
Laboratory of Chemical-Biological Interactions and Animal Reproduction, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
7
Nanomaterials Laboratory, Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Abstract

Nanodiamonds (NDs), multiwalled carbon nanotubes (MWCNTs) and gold nanorods (NRs) can be functionalized to promote gene delivery to hard-to-transfect cells with higher transfection efficiency than cationic lipids, and inducing less cell death.

PMID:
26486874
DOI:
10.1039/c5nr04173b
[Indexed for MEDLINE]

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