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Am J Ind Med. 2013 Dec;56(12):1452-62. doi: 10.1002/ajim.22266. Epub 2013 Oct 10.

Opioid poisonings and opioid adverse effects in workers in Washington state.

Author information

1
Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington.

Abstract

OBJECTIVE:

To examine trends in opioid poisonings and adverse effects in Washington (WA) State and nationally.

METHODS:

We calculated rates of opioid poisonings and adverse effects and examined opioid prescriptions in the WA workers' compensation system, 2004-2010. Using Health Care Cost and Utilization Project (HCUP), Nationwide Inpatient Sample (NIS) data, we also calculated national rates of opioid poisonings and adverse effects, 1993-2010.

RESULTS:

We identified 96 opioid poisonings and 312 opioid-related adverse effects in WA, 2004-2010. The rates did not change substantially over these years. Most poisonings and adverse effects occurred in cases without chronic opioid use and with prescribed doses <120 mg/day morphine-equivalent dose. Nationally, the rates of opioid poisonings and adverse effects increased significantly from 1993 to 2010.

CONCLUSIONS:

Many poisonings and adverse effects occurred in patients without high dose or long-term opioid therapy, suggesting that opioid dosing and duration guidelines may not be sufficient to reduce morbidity related to prescription opioid use.

KEYWORDS:

Nationwide Inpatient Sample; opioid; opioid adverse effect; opioid morbidity; opioid poisoning; workers' compensation

PMID:
24122929
DOI:
10.1002/ajim.22266
[Indexed for MEDLINE]

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