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Items: 1 to 20 of 128

1.

HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.

Mo X, Tang C, Niu Q, Ma T, Du Y, Fu H.

Cell Chem Biol. 2018 Nov 29. pii: S2451-9456(18)30433-1. doi: 10.1016/j.chembiol.2018.11.011. [Epub ahead of print]

PMID:
30639259
2.

Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.

Rusnak L, Tang C, Qi Q, Mo X, Fu H.

J Mol Cell Biol. 2018 Dec 1;10(6):549-558. doi: 10.1093/jmcb/mjy061.

PMID:
30496488
3.

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X.

J Med Chem. 2018 Nov 15. doi: 10.1021/acs.jmedchem.8b01219. [Epub ahead of print]

PMID:
30392349
4.

Polyethylene-glycol-coated gold nanoparticles improve cardiac function after myocardial infarction in mice.

Tian A, Yang C, Zhu B, Wang W, Liu K, Jiang Y, Qiao Y, Fu H, Li Z.

Can J Physiol Pharmacol. 2018 Dec;96(12):1318-1327. doi: 10.1139/cjpp-2018-0227. Epub 2018 Nov 1.

PMID:
30383982
5.

In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.

Grzeskowiak CL, Kundu ST, Mo X, Ivanov AA, Zagorodna O, Lu H, Chapple RH, Tsang YH, Moreno D, Mosqueda M, Eterovic K, Fradette JJ, Ahmad S, Chen F, Chong Z, Chen K, Creighton CJ, Fu H, Mills GB, Gibbons DL, Scott KL.

Nat Commun. 2018 Jul 16;9(1):2732. doi: 10.1038/s41467-018-04572-3.

6.

Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening.

Mady ASA, Liao C, Bajwa N, Kump KJ, Abulwerdi FA, Lev KL, Miao L, Grigsby SM, Perdih A, Stuckey JA, Du Y, Fu H, Nikolovska-Coleska Z.

Sci Rep. 2018 Jul 5;8(1):10210. doi: 10.1038/s41598-018-27899-9.

7.

Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway.

Chen M, Hu C, Guo Y, Jiang R, Jiang H, Zhou Y, Fu H, Wu M, Zhang X.

Oncol Rep. 2018 Sep;40(3):1339-1347. doi: 10.3892/or.2018.6531. Epub 2018 Jun 27.

8.

Repositioning Dopamine D2 Receptor Agonist Bromocriptine to Enhance Docetaxel Chemotherapy and Treat Bone Metastatic Prostate Cancer.

Yang Y, Mamouni K, Li X, Chen Y, Kavuri S, Du Y, Fu H, Kucuk O, Wu D.

Mol Cancer Ther. 2018 Sep;17(9):1859-1870. doi: 10.1158/1535-7163.MCT-17-1176. Epub 2018 Jun 15.

PMID:
29907594
9.

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.

Sime W, Niu Q, Abassi Y, Masoumi KC, Zarrizi R, Køhler JB, Kjellström S, Lasorsa VA, Capasso M, Fu H, Massoumi R.

Cell Death Dis. 2018 May 1;9(5):458. doi: 10.1038/s41419-018-0500-6.

10.

Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction.

Xiong J, Pecchi VG, Qui M, Ivanov AA, Mo X, Niu Q, Chen X, Fu H, Du Y.

Assay Drug Dev Technol. 2018 Feb/Mar;16(2):96-106. doi: 10.1089/adt.2017.835.

PMID:
29634317
11.

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X.

J Med Chem. 2018 Apr 12;61(7):3193-3208. doi: 10.1021/acs.jmedchem.8b00261. Epub 2018 Mar 23.

12.

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.

Huard DJE, Crowley VM, Du Y, Cordova RA, Sun Z, Tomlin MO, Dickey CA, Koren J 3rd, Blair L, Fu H, Blagg BSJ, Lieberman RL.

ACS Chem Biol. 2018 Apr 20;13(4):933-941. doi: 10.1021/acschembio.7b01083. Epub 2018 Feb 20.

13.

Dual gene activation and knockout screen reveals directional dependencies in genetic networks.

Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT.

Nat Biotechnol. 2018 Feb;36(2):170-178. doi: 10.1038/nbt.4062. Epub 2018 Jan 15.

14.

The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery.

Ivanov AA, Revennaugh B, Rusnak L, Gonzalez-Pecchi V, Mo X, Johns MA, Du Y, Cooper LAD, Moreno CS, Khuri FR, Fu H.

Bioinformatics. 2018 Apr 1;34(7):1183-1191. doi: 10.1093/bioinformatics/btx743.

PMID:
29186335
15.

Regulation of ASK1 signaling by scaffold and adaptor proteins.

Rusnak L, Fu H.

Adv Biol Regul. 2017 Dec;66:23-30. doi: 10.1016/j.jbior.2017.10.003. Epub 2017 Oct 16. Review.

PMID:
29102394
16.

PRAS40 promotes NF-κB transcriptional activity through association with p65.

Zhu G, Qi Q, Havel JJ, Li Z, Du Y, Zhang X, Fu H.

Oncogenesis. 2017 Sep 25;6(9):e381. doi: 10.1038/oncsis.2017.80.

17.

14-3-3ζ binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors.

Gu Y, Xu K, Torre C, Samur M, Barwick BG, Rupji M, Arora J, Neri P, Kaufman J, Nooka A, Bernal-Mizrachi L, Vertino P, Sun SY, Chen J, Munshi N, Fu H, Kowalski J, Boise LH, Lonial S.

Leukemia. 2018 Mar;32(3):744-751. doi: 10.1038/leu.2017.288. Epub 2017 Sep 19.

PMID:
28924240
18.

Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism.

Xiong F, Jiang M, Chen M, Wang X, Zhang S, Zhou J, Li K, Sheng Y, Yin L, Tang Y, Ye L, Wu M, Fu H, Zhang X.

J Cancer. 2017 Jul 23;8(13):2449-2455. doi: 10.7150/jca.17720. eCollection 2017.

19.

Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.

Qi Q, Obianyo O, Du Y, Fu H, Li S, Ye K.

J Med Chem. 2017 Sep 14;60(17):7244-7255. doi: 10.1021/acs.jmedchem.7b00228. Epub 2017 Aug 18.

20.

OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.

Ivanov AA, Gonzalez-Pecchi V, Khuri LF, Niu Q, Wang Y, Xu Y, Bai Y, Mo X, Prochownik EV, Johns MA, Du Y, Khuri FR, Fu H.

Oncogene. 2017 Oct 19;36(42):5852-5860. doi: 10.1038/onc.2017.180. Epub 2017 Jun 19.

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