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See 1 citation in Front Cell Dev Biol 2018:

Front Cell Dev Biol. 2018 Feb 13;6:13. doi: 10.3389/fcell.2018.00013. eCollection 2018.

Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins.

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Université de Lyon, Centre de Recherche en Cancérologie de Lyon, U1052 Institut National de la Santé et de la Recherche Médicale, UMR Centre National de la Recherche Scientifique 5286, Université Lyon I, Centre Léon Bérard, Lyon, France.
Hospices Civils de Lyon, Laboratoire d'anatomie et Cytologie Pathologiques, Centre Hospitalier Lyon Sud, Pierre Bénite, France.


Bcl-2 family proteins are recognized as major regulators of the mitochondrial pathway of apoptosis. They control the mitochondrial outer membrane permeabilization (MOMP) by directly localizing to this organelle. Further investigations demonstrated that Bcl-2 related proteins are also found in other intracellular compartments such as the endoplasmic reticulum, the Golgi apparatus, the nucleus and the peroxisomes. At the level of these organelles, Bcl-2 family proteins not only regulate MOMP in a remote fashion but also participate in major cellular processes including calcium homeostasis, cell cycle control and cell migration. With the advances of live cell imaging techniques and the generation of fluorescent recombinant proteins, it became clear that the distribution of Bcl-2 proteins inside the cell is a dynamic process which is profoundly affected by changes in the cellular microenvironment. Here, we describe the current knowledge related to the subcellular distribution of the Bcl-2 family of proteins and further emphasize on the emerging concept that this highly dynamic process is critical for cell fate determination.


Bcl-2 family; endoplasmic reticulum; mitochondria; nucleus; subcellular localization

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