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PLoS One. 2015 Apr 13;10(4):e0124239. doi: 10.1371/journal.pone.0124239. eCollection 2015.

Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study.

Collaborators (267)

Domínguez S, Onrubia Pintado JA, Toral Cañas JC, Cumplido Burón JD, Pérez Altozano J, Martínez Banaclocha N, Juarez Marroquí A, Gálvez Muñoz E, Meana García A, Aparisi Aparisi Fde A, Sureda González M, Rosillo Fernández FE, Valle M, Maldonado Seral C, Palacio Vazquez I, Berros Fombella JP, Álvarez Cuesta CC, Godoy Gijón E, Peláez I, Fernández Martínez R, Sampedro T, Fernández IC, Jaraquemada Peláez MT, Arrivi A, Cordero N, Díaz Verde P, Martín Broto J, del Pozo Hernando LJ, Luna Fra P, Mut Sanchís P, García García Y, Blanco Guerrero R, Arance A, Carrera Alvarez C, Visa Turmo E, Puig Sardà S, Montesinos Muñoz J, Aya F, Puig JA, Losa Gaspa F, Majem M, López Fernández S, Lianes P, Sabat Santandreu M, Montagut Viladot C, Muñoz E, Cortés J, Lucas A, Martínez Cardús A, Gutierrez C, Marcoval J, Caminal JM, Piulats Rodríguez JM, Pera J, Goma M, Penin R, Boada García A, Mañes García A, Moretones Agut C, Manzano Mozo JL, Ochoa de Olza M, Mayo de las Casas C, González Cao M, Jordana Ariza N, Mederos N, Rosell Costa R, Crespo Herrero G, García Girón C, Collado Martín R, López Sánchez D, Martínez Rodríguez A, García Castaño A, Vaqué Diez JP, Munarriz Ferrandis J, Jiménez J, Benitez Goma JR, Afonso FJ, de la Cámara J, Curiel García MT, Quindós Varela M, F Bande M, Valladares M, Rubio Casadevall J, Belón Carrión J, Jurado JM, Valdés C, Valdivia J, López E, Holgado Martín E, Cassinello Espinosa J, Basterretxea Badiola L, Arias-Camisón Montero I, Mujika Eizmendi K, Lastra del Prado R, Nieto B, Samaniego E, Pedraza M, Gutierrez Sanz L, Eugenia OI, Javier GN, Martí Laborda RM, Campos Balea B, Teixidó Calvo J, Calvo E, López Rios F, Rodríguez Moreno JF, Mezquita Pérez L, Riveiro E, Soengas M, Fernández-Chacón de Lucas C, Espinosa Lara P, López Criado P, Pizarro Redondo Á, Molina Ruiz AM, Casado Echarren V, Cubedo Cervera R, Olier C, Aguado Lobo M, Galván Casas C, González Larriba JL, Fernández-Chacón C, Juez I, Alonso Muñoz A, Márquez I, Avilés JA, Parra V, Escobar Álvarez Y, González Paz C, Mauleón Fernández C, Chavarría Mur E, Zambrana Tévar F, Sereno Moyano M, Bautista Sirvent FJ, Villalobos León ML, Alés Fernández M, Soria Rivas A, Guillén Ponce C, Cabañas Montero J, Cabañas L, Ríos Buceta L, Martín MM, Homet B, López Martín JA, Rodríguez Peralto JL, Ortíz Romero PL, Pascual Martínez T, Sanz Motilva V, Ballesteros García AI, Delgado Jiménez Y, Cabezón Gutiérrez L, Gómez Fernández C, Espinosa Arranz E, Mayor Arenal M, Feito Rodríguez M, Alonso Carrión L, Martín D, Pérez Ruiz E, Fernández Canedo MI, de Troya Martín M, Blázquez Sánchez N, Montesa Pino Á, Bretón García JJ, Berciano Guerrero MA, Martínez García S, Ballester Navarro I, Cerezuela Fuentes P, García de Guadiana R, Bernal Mañas CM, Ballester Nortes I, Balsalobre Salmerón MD, Montalbán Romero S, Ortíz S, Piñero A, Martínez Escribano J, Ros Martínez S, Gurpide A, Alfaro Alegría C, Echenique Gubia I, Goicoechea Goicoechea I, Melero I, Echeveste JI, Pérez Gracia JL, Soria Royo L, Zubiri L, Idoate MA, Martínez Cosgaya MC, Fernández de Sanmamed M, Martínez Álvarez Nava MJ, Lozano MD, Redondo P, Martín Algarra S, Labiano T, Lecumberri MJ, Morilla Ruiz I, Gil I, Fernández Calvo O, Barea Bejarano JL, Rodríguez Abreu D, Almeida Martín P, Carretero Hernández G, Saura Grau S, Santome Couto L, Martín Carnicero A, González Labasa MA, Santos-Briz Terrón Á, Roman Curto C, Cañueto Álvarez J, Bellido Hernández L, Cabrera Suárez MA, Fernández de Misa R, Oramas Rodríquez J, Rios JJ, Grueso A, Moreno D, de la Cruz Merino L, Fernández Pulido L, Ferrándiz Pulido L, Codes M, de la Borbolla Artacho MR, Sancho MP, Pastor P, Martínez Madueño F, Corral Subias M, Yubero Esteban A, Vera Iglesias E, Barrios FJ, González Ageitos A, Sánchez Moya AI, Medina J, Berrocal Jaime A, Pinazo Canales I, Escrig Orenga V, Lorca Chapa J, Garcerá S, Martorell Calatayud A, Royo Peiró Á, Escutia Muñoz B, Muñoz Langa J, Montalar J, Botella R, Díaz Beveridge R, Nagore E, Soriano Teruel V, López Castro R, Fra Rodríguez J, Villanueva Silva MJ, sdfsdf E, Sande L, Fernández Rodríguez R, Sánchez Díez A, Valdés C, Pérez Hoyos MT, Martínez del Prado P, Fuente Fernández N, Garicano López F, Boyano López MD, Mayordomo Cámara JI, Puértolas Hernández T, Carranza Rua OE, Cerdá B, Serra Bellvar P, Martínez H, de la Garza J, Vargas Quesada A, von Euw EM, Ribas A, Peinado Selgas H.

Author information

1
Servicio de Oncología Médica, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
2
Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, Spain.
3
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.
4
Servicio de Dermatología, Hospital La Paz, Madrid, Spain.
5
Servicio de Dermatología, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
6
Servicio de Deramtología, Hospital Universitario Central de Asturias, Oviedo, Spain.
7
Servicio de Oncología Médica, Instituto Valenciano de Oncología, Valencia, Spain.
8
Servicio de Oncología Médcica, Hospital de Sant Pau, Barcelona, Spain.
9
Servicio de Oncología Médica, Hospital General de Valencia, Valencia, Spain.
10
Servicio de Oncología Médica, Hospital de San Pedro, Logroño, Spain.
11
Servicio de Oncología, Hospital Universitario Miguel Servet, Zaragoza, Spain.
12
Servicio de Dermatología, Hospital de Cabueñes, Gijon, Spain.
13
Servicio de Oncología Médica, Hospital General Universitario Santa Lucia, Cartagena, Spain.
14
Servicio de Oncología Médica, Instituto Catalan de Oncología, Hospitalet, Spain.
15
Servicio de Oncología Médica, Hospital Lucus Augusti, Lugo, Spain.
16
Servicio de Oncología Médica, Hospital Costa del Sol, Marbella, Spain.
17
Servicio de Oncología Médica, Hospital Ramón y Cajal, Madrid, Spain.
18
Servicio de Oncología Medica, Hospital Reina Sofía, Tudela, Spain.
19
Servico de Oncología Médica, Instituto Dexeus, Barcelona, Spain.
20
Servicio de Oncología Médica, Hospital de Elda, Alicante, Spain.
21
Servicio de Oncología Medica, Hospital Clinic, Barcelona, Spain.
22
Servicio de Oncología Médica, Clínica Oncogranada, Granada, Spain.
23
Servicio de Oncología Médica, Hospital Virgen de la Macarena, Sevilla, Spain.
24
Departamento de Oncología, Clínica Universidad de Navarra, Pamplona, Spain.

Abstract

INTRODUCTION:

Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain.

PATIENTS AND METHODS:

An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments.

RESULTS:

In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups.

CONCLUSIONS:

Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior.

PMID:
25874698
PMCID:
PMC4395344
DOI:
10.1371/journal.pone.0124239
[Indexed for MEDLINE]
Free PMC Article

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