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Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Yoshino M, et al. Among authors: franczyk mp. Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. Science. 2021. PMID: 33888596 Free PMC article. Clinical Trial.
Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism.
Yamaguchi S, Kojima D, Iqbal T, Kosugi S, Franczyk MP, Qi N, Sasaki Y, Yaku K, Kaneko K, Kinouchi K, Itoh H, Hayashi K, Nakagawa T, Yoshino J. Yamaguchi S, et al. Among authors: franczyk mp. Biochem Biophys Res Commun. 2023 Sep 24;674:162-169. doi: 10.1016/j.bbrc.2023.07.007. Epub 2023 Jul 4. Biochem Biophys Res Commun. 2023. PMID: 37421924
Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility.
Franczyk MP, Qi N, Stromsdorfer KL, Li C, Yamaguchi S, Itoh H, Yoshino M, Sasaki Y, Brookheart RT, Finck BN, DeBosch BJ, Klein S, Yoshino J. Franczyk MP, et al. Endocrinology. 2021 Mar 1;162(3):bqab006. doi: 10.1210/endocr/bqab006. Endocrinology. 2021. PMID: 33543238 Free PMC article.
Adipose tissue NAD+ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice.
Yamaguchi S, Franczyk MP, Chondronikola M, Qi N, Gunawardana SC, Stromsdorfer KL, Porter LC, Wozniak DF, Sasaki Y, Rensing N, Wong M, Piston DW, Klein S, Yoshino J. Yamaguchi S, et al. Among authors: franczyk mp. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23822-23828. doi: 10.1073/pnas.1909917116. Epub 2019 Nov 6. Proc Natl Acad Sci U S A. 2019. PMID: 31694884 Free PMC article.
NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism.
Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J. Porter LC, et al. Among authors: franczyk mp. Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E520-E530. doi: 10.1152/ajpendo.00057.2018. Epub 2018 Apr 10. Am J Physiol Endocrinol Metab. 2018. PMID: 29634313 Free PMC article.