Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Fertil Steril. 2011 Feb;95(2):804.e7-10. doi: 10.1016/j.fertnstert.2010.07.1072.

Four spontaneous pregnancies and three live births following subcutaneous transplantation of frozen banked ovarian tissue: what is the explanation?

Author information

1
Department of Obstetrics and Gynecology, Institute for Fertility Preservation, New York Medical College-Westchester Medical Center, Valhalla, New York 10595, USA. koktay@fertilitypreservation.org

Abstract

OBJECTIVE:

To report the long-term follow-up of an experimental heterotopic ovarian transplantation with frozen-thawed ovarian tissue.

DESIGN:

Long-term follow-up of an experimental surgery; case report.

SETTING:

Academic reproductive medicine center.

PATIENT(S):

A 28-year-old cancer survivor with previous Hodgkin disease and relapse.

INTERVENTION(S):

Laparoscopic oophorectomy for ovarian cryopreservation before preconditioning chemotherapy for hematologic stem cell transplantation. Ovarian tissue thawing and subcutaneous heterotopic ovarian transplantation in the lower abdominal wall 2½ years after the hematologic stem cell transplantation.

MAIN OUTCOME MEASURE(S):

Resumption of ovarian function after transplantation, recovery of fertility, and pregnancy outcome.

RESULT(S):

Follicle development was observed in the graft 2 months after transplantation, and a P value of 14 ng/mL indicated ovulation. The patient conceived spontaneously four times within 5 years and delivered three children. The in situ ovary remained atrophic but showed occasional follicle activity contemporaneously with the graft.

CONCLUSION(S):

The mechanism behind spontaneous restoration of fertility with consecutive viable pregnancies after a heterotopic ovarian transplantation needs to be explored. Further laboratory and clinical research will be needed to explore the true origin of pregnancies after ovarian transplantations.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center