Format

Send to

Choose Destination

See 1 citation found by title matching your search:

BMJ Case Rep. 2015 Sep 23;2015. pii: bcr2015210961. doi: 10.1136/bcr-2015-210961.

First use of bedaquiline in a patient with XDR-TB in Singapore.

Author information

1
TB Control Unit, Tan Tock Seng Hospital, Singapore, Singapore.
2
Department of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.
3
Department of Respiratory Medicine, TB Control Unit, Tan Tock Seng Hospital, Singapore, Singapore.

Abstract

Drug-resistant tuberculosis (TB) continues to pose a threat to global control of TB: 3.5% of new and 20.5% of previously treated TB cases were estimated to have multidrug-resistant (MDR)-TB in 2013. Approximately 9% of patients with MDR-TB had extensively drug-resistant (XDR)-TB. A 30-year-old Vietnamese woman previously treated for TB in her home country presented with 5 months of cough and shortness of breath 1 year after migrating to Singapore. Xpert MTB/Rif testing showed rpoB gene mutation. Phenotypic drug susceptibility testing revealed XDR-TB. Second and third-line TB drugs were commenced. To strengthen the efficacy of her treatment regimen, the novel anti-TB drug bedaquiline was obtained for the patient on compassionate grounds. We report the first use in Singapore of bedaquiline for the treatment of XDR-TB.

PMID:
26400590
PMCID:
PMC4593274
DOI:
10.1136/bcr-2015-210961
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center