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Fertil Steril. 2009 Jun;91(6):2338-43. doi: 10.1016/j.fertnstert.2008.03.017. Epub 2008 Apr 28.

Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis.

Author information

1
Department of Obstetrics & Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China. cqyangz@vip.163.com

Abstract

OBJECTIVE:

To investigate the feasibility of laparoscopic high-intensity focused ultrasound (HIFU) ablation in the treatment of patients with uterine localized adenomyosis.

DESIGN:

A prospective clinical trial.

SETTING:

University teaching hospital.

PATIENT(S):

Seven patients with uterine localized adenomyosis.

INTERVENTION(S):

Using a hand-held focused ultrasound transducer, the HIFU procedure was performed by the same gynecologist for the treatment of a targeted adenomyosis during the surgical procedure, followed by hysterectomy.

MAIN OUTCOME MEASURE(S):

Feasibility and effectiveness of HIFU treatment of localized adenomyomas.

RESULT(S):

Macroscopic and microscopic examinations showed that HIFU induced thermal ablation of a targeted adenomyosis in all patients. The treated adenomyosis presented typical characteristics of coagulation necrosis, and the margin between the treated and untreated regions was clear in 2,3,5-triphenyltetrazolium chloride staining. By using electronic microscopy and nicotinamide adenine dinucleotide-diaphorase stain, complete loss of cellular viability was identified in the treated tissue.

CONCLUSION(S):

The HIFU treatment is feasible and effective in the treatment of patients with uterine localized adenomyosis. It may provide a promising laparoscopic treatment for localized adenomyosis.

[Indexed for MEDLINE]

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