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Schizophr Res. 2015 Mar;162(1-3):64-6. doi: 10.1016/j.schres.2015.01.013. Epub 2015 Jan 28.

Factors contributing to the duration of untreated prodromal positive symptoms in individuals at ultra-high risk for psychosis.

Author information

1
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
2
Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
3
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
4
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
5
Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
6
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea; Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. Electronic address: kwonjs@snu.ac.kr.

Abstract

Individuals at ultra-high risk (UHR) for psychosis experience a considerable delay before appropriate clinical attention is provided. Therefore, we investigated the correlates of this delay by examining clinical, socio-demographic and neuropsychological contributors to the duration of untreated prodromal positive symptoms (DUPP) in them (n=73). The slowly progressive mode of functional decline, defined as a small percentage drop in the Global Assessment of Functioning (GAF) score within the past year, and male gender, explained a considerable portion of the DUPP in the multivariate regression model (F=9.269, p<0.001). Slower functional decline may be correlated with delayed care during the UHR period.

KEYWORDS:

Delayed care; Duration of untreated prodromal positive symptoms; Functional decline; Psychosis; Ultra-high risk for psychosis

PMID:
25636994
DOI:
10.1016/j.schres.2015.01.013
[Indexed for MEDLINE]

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