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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1954 2
1970 2
1973 1
1974 1
1976 1
1978 1
1979 1
1980 1
1981 2
1983 1
1984 1
1985 6
1987 4
1988 5
1989 10
1990 17
1991 23
1992 62
1993 73
1994 115
1995 111
1996 118
1997 120
1998 113
1999 124
2000 115
2001 130
2002 121
2003 133
2004 135
2005 137
2006 121
2007 159
2008 166
2009 143
2010 149
2011 144
2012 155
2013 138
2014 145
2015 144
2016 113
2017 146
2018 128
2019 131
2020 149
2021 131
2022 145
2023 119
2024 40

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3,908 results

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Page 1
FYN: emerging biological roles and potential therapeutic targets in cancer.
Peng S, Fu Y. Peng S, et al. J Transl Med. 2023 Feb 5;21(1):84. doi: 10.1186/s12967-023-03930-0. J Transl Med. 2023. PMID: 36740671 Free PMC article. Review.
Moreover, FYN is involved in the regulation of multiple cancer-related signaling pathways, including interactions with ERK, COX-2, STAT5, MET and AKT. FYN is therefore an attractive therapeutic target for various tumor types, and suppressing FYN can improve t …
Moreover, FYN is involved in the regulation of multiple cancer-related signaling pathways, including interactions with ERK, COX-2, ST …
Role of Fyn in hematological malignancies.
Li S, Liu C, Tang Y. Li S, et al. J Cancer Res Clin Oncol. 2023 Aug;149(9):6759-6767. doi: 10.1007/s00432-023-04608-2. Epub 2023 Feb 8. J Cancer Res Clin Oncol. 2023. PMID: 36754870 Review.
BACKGROUND: Tyrosine kinase Fyn is a member of the Src family of kinases. In addition to the wild type, three mRNA splice isoforms of Fyn have been identified; Fyn-B, Fyn-T, and Fyn-C. ...CONCLUSION: Fyn could be a novel prognostic marker …
BACKGROUND: Tyrosine kinase Fyn is a member of the Src family of kinases. In addition to the wild type, three mRNA splice isoforms of …
Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways.
Marotta G, Basagni F, Rosini M, Minarini A. Marotta G, et al. Curr Med Chem. 2022;29(27):4738-4755. doi: 10.2174/0929867329666211221153719. Curr Med Chem. 2022. PMID: 34939537 Review.
Fyn kinase is a member of the Src non-receptor tyrosine kinase family. ...However, Fyn is also a challenging target since the Fyn inhibitors discovered so far, due to the relevant homology of Fyn with other kinases, suffer from off-target effects. ...
Fyn kinase is a member of the Src non-receptor tyrosine kinase family. ...However, Fyn is also a challenging target since the …
FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer.
Peng S, Yin Y, Zhang Y, Zhu F, Yang G, Fu Y. Peng S, et al. J Exp Clin Cancer Res. 2023 Apr 4;42(1):80. doi: 10.1186/s13046-023-02652-x. J Exp Clin Cancer Res. 2023. PMID: 37016377 Free PMC article.
The pro-cancer role of FYN in multiple malignancies has been elucidated. However, the mechanisms that FYN promotes gastric cancer (GC) progression remain largely unknown. ...Mechanistically, we identified TOPK/PBK as a novel downstream substrate of FYN, FY …
The pro-cancer role of FYN in multiple malignancies has been elucidated. However, the mechanisms that FYN promotes gastric can …
Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions.
Matrone C, Petrillo F, Nasso R, Ferretti G. Matrone C, et al. Int J Mol Sci. 2020 Jun 22;21(12):4444. doi: 10.3390/ijms21124444. Int J Mol Sci. 2020. PMID: 32580508 Free PMC article. Review.
Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. We will primarily focus on Fyn-mediated signaling pathways involved in neuronal differentiation …
Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals accor …
Targeting Fyn Kinase in Alzheimer's Disease.
Nygaard HB. Nygaard HB. Biol Psychiatry. 2018 Feb 15;83(4):369-376. doi: 10.1016/j.biopsych.2017.06.004. Epub 2017 Jun 13. Biol Psychiatry. 2018. PMID: 28709498 Free PMC article. Review.
Fyn is also a challenging target, with broad expression throughout the body and significant homology with other members of the Src family kinases, which may lead to unintended off-target effects. A phase 2a proof-of-concept clinical trial in patients with AD is currently u …
Fyn is also a challenging target, with broad expression throughout the body and significant homology with other members of the Src fa …
Direct active Fyn-paxillin interaction regulates vascular smooth muscle cell migration.
Zhang Y, Kishi H, Kobayashi S. Zhang Y, et al. J Smooth Muscle Res. 2023;59:58-66. doi: 10.1540/jsmr.59.58. J Smooth Muscle Res. 2023. PMID: 37438114 Free PMC article. Review.
Recently, we discovered a novel interaction, direct binding of active Fyn-paxillin at focal adhesions, which plays an important role in actin stress fiber formation and migration in VSMCs. In this review, we highlight paxillin as an intermediate signaling molecule that med …
Recently, we discovered a novel interaction, direct binding of active Fyn-paxillin at focal adhesions, which plays an important role …
Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury.
Uddin MJ, Dorotea D, Pak ES, Ha H. Uddin MJ, et al. Biomol Ther (Seoul). 2020 May 1;28(3):213-221. doi: 10.4062/biomolther.2019.214. Biomol Ther (Seoul). 2020. PMID: 32336052 Free PMC article. Review.
Limited studies have shown increased Fyn transcription level and activation under experimental AKI. Activated Fyn kinase propagates various downstream signaling pathways associated to the progression of AKI, such as oxidative stress, inflammation, endoplasmic reticu …
Limited studies have shown increased Fyn transcription level and activation under experimental AKI. Activated Fyn kinase propa …
Fyn in Neurodevelopment and Ischemic Brain Injury.
Knox R, Jiang X. Knox R, et al. Dev Neurosci. 2015;37(4-5):311-20. doi: 10.1159/000369995. Epub 2015 Feb 17. Dev Neurosci. 2015. PMID: 25720756 Free PMC article. Review.
The Src family kinases (SFKs) are nonreceptor protein tyrosine kinases that are implicated in many normal and pathological processes in the nervous system. The SFKs Fyn, Src, Yes, Lyn, and Lck are expressed in the brain. This review will focus on Fyn, as Fyn …
The Src family kinases (SFKs) are nonreceptor protein tyrosine kinases that are implicated in many normal and pathological processes in the …
Fyn, a potential target for Alzheimer's disease.
Yang K, Belrose J, Trepanier CH, Lei G, Jackson MF, MacDonald JF. Yang K, et al. J Alzheimers Dis. 2011;27(2):243-52. doi: 10.3233/JAD-2011-110353. J Alzheimers Dis. 2011. PMID: 21799250 Review.
Fyn also induces tyrosine phosphorylation of tau. Although many studies have implicated a role for Fyn in AD, the precise cellular and molecular mechanisms require further investigation. Novel insights into the role of Fyn in AD may help identify alternative …
Fyn also induces tyrosine phosphorylation of tau. Although many studies have implicated a role for Fyn in AD, the precise cell …
3,908 results