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Neurologia. 2014 Nov-Dec;29(9):560-6. doi: 10.1016/j.nrl.2013.04.005. Epub 2013 Jul 5.

Exploring the genetic basis of stroke. Spanish stroke genetics consortium.

[Article in English, Spanish]

Author information

1
Grupo de Investigación Neurovascular, Departamento de Neurología, IMIM-Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: 96714@parcdesalutmar.cat.
2
Grupo de Investigación Neurovascular, Departamento de Neurología, IMIM-Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España.
3
Laboratorio de Investigación Neurovascular, Institut de Recerca, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
4
Departamento de Neurología, Hospital Universitari Son Espases, Mallorca, Baleares, España.

Abstract

This article provides an overview of stroke genetics studies ranging from the candidate gene approach to more recent studies by the genome wide association. It highlights the complexity of stroke owing to its different aetiopathogenic mechanisms, the difficulties in studying its genetic component, and the solutions provided to date. The study emphasises the importance of cooperation between the different centres, whether this takes places occasionally or through the creation of lasting consortiums. This strategy is currently essential to the completion of high-quality scientific studies that allow researchers to gain a better knowledge of the genetic component of stroke as it relates to aetiology, treatment, and prevention.

KEYWORDS:

Asociación; Association; Consorcio; Consortium; Factores de riesgo genético; Genetic risk factors; Genetics; Genética; Ictus; Predicción; Prediction; Stroke

PMID:
23831412
DOI:
10.1016/j.nrl.2013.04.005
[Indexed for MEDLINE]
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