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Trends Mol Med. 2012 Sep;18(9):503-5. doi: 10.1016/j.molmed.2012.07.003. Epub 2012 Aug 3.

Exploring the endocrine manifestations of DICER1 mutations.

Author information

1
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Subiaco, Western Australia 6008, Australia.

Abstract

The discovery of each new cancer susceptibility gene answers one set of questions but poses many more. In this article, we outline a recent example: a new cancer syndrome caused by germline mutations in DICER1, responsible for microRNA processing. In particular, we discuss the endocrine manifestations of mutations in this crucial gene.

PMID:
22867905
DOI:
10.1016/j.molmed.2012.07.003
[Indexed for MEDLINE]

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