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Histopathology. 2019 Feb;74(3):443-451. doi: 10.1111/his.13755. Epub 2018 Dec 5.

Expanding the morphological spectrum of ovarian microcystic stromal tumour.

Author information

1
Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.
2
Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada.
3
Department of Pathology, Royal Marsden Hospital, London, UK.
4
Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network, Toronto, ON, Canada.
5
Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
6
Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.

Abstract

AIMS:

To expand the morphological spectrum of ovarian microcystic stromal tumour, a rare neoplasm considered to have a relatively constant morphology with microcysts, solid cellular regions and hyalinised fibrous stroma.

METHODS AND RESULTS:

We report four ovarian neoplasms in patients aged 45, 56, 61 and 71 years with the characteristic immunophenotype of microcystic stromal tumour (diffuse nuclear positivity with beta-catenin, cyclin D1 and WT1; diffuse cytoplasmic positivity with CD10; negative inhibin, calretinin, oestrogen receptor and progesterone receptor). The tumours had variant morphology (diffuse, nested and corded arrangements in three cases, including one with spindle cell elements; nested, corded and tubular in the other). A CTNNB1 point mutation in exon 3 (c.98C>G,p.S33C; c.100G>A,p.G34R; c.97T>G,p.S33A) was present in the three cases with material available for testing.

CONCLUSIONS:

We feel that the cases we report are related to microcystic stromal tumour but with variant morphology; as such, the morphological spectrum of ovarian microcystic stromal tumour is broader than hitherto reported.

KEYWORDS:

androgen receptor; beta-catenin; immunohistochemistry; microcystic stromal tumour; ovary; variant morphology

PMID:
30325056
DOI:
10.1111/his.13755
[Indexed for MEDLINE]

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