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J Gen Fam Med. 2017 Aug 29;18(6):432-435. doi: 10.1002/jgf2.108. eCollection 2017 Dec.

Exercise-induced acute renal failure in a trainee cyclist without hypouricemia: Successful athletic career post-treatment.

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Department of Nephrology Otsu Red-Cross Hospital Otsu Japan.


Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise (ALPE) is exercise-induced acute renal failure that occurs without myoglobinuria. We describe a typical case involving an 18-year-old man. Generally, patients with ALPE are advised to avoid anaerobic exercise due to risk of recurrence, but our patient continued and went on to become a professional cyclist without relapse. About 51% of ALPE cases involve patients with renal hypouricemia. His serum uric acid levels were rather high, at 6.4 mg/dL. He is the first patient with ALPE to succeed as a professional athlete in an anaerobic sport.


ALPE; acute kidney injury; acute renal failure; exercise; renal hypouricemia

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