Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Alzheimers Dement. 2018 Jun;14(6):837-842. doi: 10.1016/j.jalz.2018.02.010. Epub 2018 Mar 28.

European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials.

Author information

1
Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: L.Vermunt@vumc.nl.
2
Department of Genetics, University of Leicester, Leicester, UK.
3
Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
4
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
5
Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland; Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
6
National Institute for Health and Welfare, Helsinki, Finland; Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden; University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
7
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy.
8
Neurología, Fundación CITA-Alzhéimer Fundazioa, Centro de Investigación y Terapias Avanzadas, San Sebastián, Guipúzcoa, Spain.
9
BarcelonaBeta Brain Research Center, Fundacio Pasqual Maragall, Universitat Pompeu Fabra, Barcelona, Spain; Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain.
10
Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
11
Institut National de la Sante et de la Recherche Medicale, U1061 Neuropsychiatrie, Montpellier, France; University of Montpellier, Montpellier, France; Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
12
Department of Geriatric Medicine, CHU Toulouse, Gerontopole and INSERM UMR 1027, Toulouse, France.
13
Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
14
Global Innovative Pharma Business - Clinical Sciences, Pfizer, Paris, France.
15
Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.

Abstract

INTRODUCTION:

It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.

METHODS:

A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.

RESULTS:

To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.

DISCUSSION:

This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

KEYWORDS:

Clinical trial; EPAD; Participant recruitment; Preclinical AD; Prodromal AD; Research registry

PMID:
29604264
DOI:
10.1016/j.jalz.2018.02.010

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center