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See 1 citation in Eur Heart J 2014:

Eur Heart J. 2014 Aug 14;35(31):2106-14. doi: 10.1093/eurheartj/ehu151. Epub 2014 Apr 11.

Assessment of microRNAs in patients with unstable angina pectoris.

Author information

1
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246 Hamburg, Germany German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, Germany.
2
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246 Hamburg, Germany German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany.
3
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246 Hamburg, Germany.
4
Department of Internal Medicine, University Hospital, Basel, Switzerland Department of Cardiology, University Hospital, Basel, Switzerland.
5
Department of Medicine II, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
6
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany Department of Medicine II, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany Clinical Epidemiology, Center for Thrombosis and Haemostasis, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
7
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany Department of Laboratory Medicine, University Medical Center, Johannes Gutenberg University Mainz, Germany.
8
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany Department of Medicine II, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
9
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246 Hamburg, Germany German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, Germany s.blankenberg@uke.de.

Abstract

AIMS:

While cardiac troponin measurements have significantly improved the early diagnosis of myocardial infarction, the timely biomarker-based diagnosis of unstable angina pectoris (UAP) remains a major unmet clinical challenge. The aim of this study was to assess levels of circulating microRNAs (miRNAs) as possible novel biomarkers in patients with UAP.

METHODS AND RESULTS:

A three-phase approach was conducted, comprising (i) profiling of miRNAs in patients with UAP and controls groups; (ii) replication of significant miRNAs in an independent patient cohort, (iii) validation of a multi-miRNAs panel in a third cohort. Out of 25 miRNAs selected for replication, 8 miRNAs remained significantly associated with UAP. In a validation phase, a miRNA panel including miR-132, miR-150, and miR-186 showed the highest discriminatory power [area under the receiver-operating-characteristic curve (AUC): 0.91; CI: 0.84-0.98].

CONCLUSION:

Using a profiling-replication-validation model, we identified eight miRNAs, which may facilitate the diagnosis of UAP.

KEYWORDS:

Acute myocardial infarction; Circulating microRNA; Diagnosis; Myocardial infarction; Unstable angina pectoris

PMID:
24727883
DOI:
10.1093/eurheartj/ehu151
[Indexed for MEDLINE]

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