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Radiat Prot Dosimetry. 2009 Feb;134(1):23-9. doi: 10.1093/rpd/ncp056. Epub 2009 Apr 4.

Estimating the lung burden from exposure to aerosols of depleted uranium.

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Uranium Medical Research Center, Shawville, Quebec, Canada.


Following exposure to aerosols of depleted uranium (DU), biological samples show the presence of a synthetic mixture of natural uranium and DU. By partitioning the uranium in the 24-h urine sample along the isotopic fractions of natural uranium and DU, one can study the kinetics of these subpopulations independently. A linear model is developed to estimate the lung burden of DU from measurements of DU in 24-h urine samples, years after inhalational exposure to aerosols of DU. This model takes into account the intracellular dissolution of the retained particles and the precipitation of a significant fraction of the dissolved DU as insoluble uranyl phosphates.

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