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Contemp Clin Trials. 2016 May;48:46-51. doi: 10.1016/j.cct.2016.03.011. Epub 2016 Mar 23.

Enhancing panic and smoking reduction treatment with d-cycloserine: Study protocol for a randomized controlled trial.

Author information

1
Department of Psychology, Institute for Mental Health Research, University of Texas at Austin, Austin, TX, United States. Electronic address: smits@utexas.edu.
2
Department of Psychology, University of Houston, Houston, TX, United States.
3
Department of Psychology, Institute for Mental Health Research, University of Texas at Austin, Austin, TX, United States.
4
Department of Psychology, University of Houston, Houston, TX, United States; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
5
Psychological and Brain Sciences, Boston University, Boston, MA, United States.
6
Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
7
Department of Psychology, Southern Methodist University, Dallas, TX, United States.

Abstract

There has been relatively little attention focused on treatment strategies for smokers with panic attacks despite their increased risk of relapse. Panic and Smoking Reduction Treatment (PSRT) integrates standard smoking cessation treatment with an exposure-based intervention targeting the mechanisms underlying panic-smoking relations. Building upon emerging evidence supporting the efficacy of d-cycloserine (DCS) for augmenting exposure-based therapy, we are conducting an initial test of the efficacy of DCS for enhancing PSRT outcomes. Utilizing a randomized, double-blind trial comparing PSRT+DCS to PSRT+placebo, we will obtain initial effect sizes for short-term and long-term smoking cessation outcomes and perform an initial test of putative mechanisms.

KEYWORDS:

Augmentation; Behavioral intervention; Clinical trial; Panic; Smoking cessation; d-Cycloserine

PMID:
27015966
PMCID:
PMC4885779
DOI:
10.1016/j.cct.2016.03.011
[Indexed for MEDLINE]
Free PMC Article

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