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Showing results for enhanced stability of tristetraprolin mrna protects mice against immune mediated inflammatory pathologies
Your search for Enhanced stability of tristetrapolin mRNA protects mice against immune-mediated inflammatory pathologies retrieved no results
Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.
Patial S, Curtis AD 2nd, Lai WS, Stumpo DJ, Hill GD, Flake GP, Mannie MD, Blackshear PJ. Patial S, et al. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1865-70. doi: 10.1073/pnas.1519906113. Epub 2016 Feb 1. Proc Natl Acad Sci U S A. 2016. PMID: 26831084 Free PMC article.
Stabilization of Tnf mRNA and other cytokine transcripts in TTP-deficient mice results in the development of a profound, chronic inflammatory syndrome characterized by polyarticular arthritis, dermatitis, myeloid hyperplasia, and autoimmunity. ...These …
Stabilization of Tnf mRNA and other cytokine transcripts in TTP-deficient mice results in the development of a profound …
Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.
Ross EA, Smallie T, Ding Q, O'Neil JD, Cunliffe HE, Tang T, Rosner DR, Klevernic I, Morrice NA, Monaco C, Cunningham AF, Buckley CD, Saklatvala J, Dean JL, Clark AR. Ross EA, et al. J Immunol. 2015 Jul 1;195(1):265-76. doi: 10.4049/jimmunol.1402826. Epub 2015 May 22. J Immunol. 2015. PMID: 26002976 Free PMC article.
Adaptive immune responses and protection against infection by Salmonella typhimurium were spared. A single allele encoding the mutant form of TTP was sufficient for enhanced mRNA degradation and underexpression of inflammatory mediators. …
Adaptive immune responses and protection against infection by Salmonella typhimurium were spared. A single allele encoding the …