Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Int J Tuberc Lung Dis. 2014 Nov;18(11):1337-9. doi: 10.5588/ijtld.14.0143.

Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.

Author information

1
Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.
2
Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
3
Medical Research Council Unit (UK), Fajara, The Gambia.
4
International Nutrition Group, Department of Nutrition and Public Health Intervention Unit, London School of Hygiene & Tropical Medicine, London, UK.

Abstract

Hepcidin inhibits ferroportin-mediated iron efflux, leading to intracellular macrophage iron retention, possibly favoring Mycobacterium tuberculosis iron acquisition and tuberculosis (TB) pathogenesis. Plasma hepcidin was measured at human immunodeficiency virus (HIV) diagnosis in a retrospective HIV-prevalent, antiretroviral-naïve African cohort to investigate the association with incident pulmonary and/or extra-pulmonary TB. One hundred ninety-six participants were followed between 5 August 1992 and 1 June 2002, with 32 incident TB cases identified. Greater hepcidin was associated with significantly increased likelihood of TB after a median time to TB of 6 months. Elucidation of iron-related causal mechanisms and time-sensitive biomarkers that identify individual changes in TB risk are needed.

PMID:
25299867
DOI:
10.5588/ijtld.14.0143
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Ingenta plc
Loading ...
Support Center