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Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.
Möller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ. Möller-Levet CS, et al. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1132-41. doi: 10.1073/pnas.1217154110. Epub 2013 Feb 25. Proc Natl Acad Sci U S A. 2013. PMID: 23440187 Free PMC article. Clinical Trial.
Insufficient sleep also reduced the number of genes with a circadian expression profile from 1,855 to 1,481, reduced the circadian amplitude of these genes, and led to an increase in the number of genes that responded to subsequent total
Insufficient sleep also reduced the number of genes with a circadian expression profile from 1,855 to 1,481, red
Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.
Arnardottir ES, Nikonova EV, Shockley KR, Podtelezhnikov AA, Anafi RC, Tanis KQ, Maislin G, Stone DJ, Renger JJ, Winrow CJ, Pack AI. Arnardottir ES, et al. Sleep. 2014 Oct 1;37(10):1589-600. doi: 10.5665/sleep.4064. Sleep. 2014. PMID: 25197809 Free PMC article.
STUDY OBJECTIVES: To address whether changes in gene expression in blood cells with sleep loss are different in individuals resistant and sensitive to sleep deprivation. ...CONCLUSION: Individual differences in behavioral effects o …
STUDY OBJECTIVES: To address whether changes in gene expression in blood cells with sleep loss are different in …
Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans.
Ackermann K, Plomp R, Lao O, Middleton B, Revell VL, Skene DJ, Kayser M. Ackermann K, et al. Chronobiol Int. 2013 Aug;30(7):901-9. doi: 10.3109/07420528.2013.784773. Epub 2013 Jun 5. Chronobiol Int. 2013. PMID: 23738906
This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young …
This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cort …