Send to

Choose Destination

See 1 citation found by title matching your search:

Nitric Oxide. 2015 Aug 1;48:10-5. doi: 10.1016/j.niox.2014.10.006. Epub 2014 Oct 24.

Effects of acute supplementation of L-arginine and nitrate on endurance and sprint performance in elite athletes.

Author information

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Center for Elite Sports Research, Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Sport, Health and Exercise Science Research Group, Department for Health, University of Bath, UK.
Wales Heart Research Institute, Department of Cardiology, Cardiff University, Cardiff, UK.
Department of Sport and Physical Education, Nord-Trøndelag University College, Levanger, Norway.
UK Sport Council, London, UK; Olympic Training Centre Berlin, Berlin, Germany.
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:


This study examined the effects of acute supplementation with L-arginine and nitrate on running economy, endurance and sprint performance in endurance-trained athletes. In a randomised cross-over, double-blinded design we compared the effects of combined supplementation with 6 g L-arginine and 614 mg nitrate against 614 mg nitrate alone and placebo in nine male elite cross-country skiers (age 18 ± 0 years, VO2max 69.3 ± 5.8 ml ⋅ min(-1) ⋅ kg(-1)). After a 48-hour standardisation of nutrition and exercise the athletes were tested for plasma nitrate and nitrite concentrations, blood pressure, submaximal running economy at 10 km ⋅ h(-1) and 14 km ⋅ h(-1) at 1% incline and 180 m as well as 5-km time-trial running performances. Plasma nitrite concentration following L-arginine + nitrate supplementation (319 ± 54 nmol ⋅ L(-1)) did not differ from nitrate alone (328 ± 107 nmol ⋅ L(-1)), and both were higher than placebo (149 ± 64 nmol ⋅ L(-1), p < 0.01). There were no differences in physiological responses during submaximal running or in 5-km performance between treatments. The plasma nitrite concentrations indicate greater nitric oxide availability both following acute supplementation of L-arginine + nitrate and with nitrate alone compared to placebo, but no additional effect was revealed when L-arginine was added to nitrate. Still, there were no effects of supplementation on exercise economy or endurance running performance in endurance-trained cross-country skiers.


Endurance athletes; Exercise economy; Nitric oxide

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center