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Pharmacogenomics J. 2016 Nov;16(6):540-550. doi: 10.1038/tpj.2015.67. Epub 2015 Oct 27.

Effect of summer daylight exposure and genetic background on growth in growth hormone-deficient children.

Author information

1
Institute of Human Development, University of Manchester and Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
2
Department Pédiatrie, Hôpital Mère-Enfant-Université Claude Bernard, Lyon, France.
3
University of Manchester, Manchester, UK.

Abstract

The response to growth hormone in humans is dependent on phenotypic, genetic and environmental factors. The present study in children with growth hormone deficiency (GHD) collected worldwide characterised gene-environment interactions on growth response to recombinant human growth hormone (r-hGH). Growth responses in children are linked to latitude, and we found that a correlate of latitude, summer daylight exposure (SDE), was a key environmental factor related to growth response to r-hGH. In turn growth response was determined by an interaction between both SDE and genes known to affect growth response to r-hGH. In addition, analysis of associated networks of gene expression implicated a role for circadian clock pathways and specifically the developmental transcription factor NANOG. This work provides the first observation of gene-environment interactions in children treated with r-hGH.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00699855.

PMID:
26503811
PMCID:
PMC5223086
DOI:
10.1038/tpj.2015.67
[Indexed for MEDLINE]
Free PMC Article

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